Referenser och källor

Nr 4 2023/1 2024 – Längre liv: Anti-aging & Longevity

Medeltida medicin i modern tappning – Ögonsalva från 800-talet dödar dagens mördarbakterier

1. Connelly E, Lee C, Furner-Pardoe J, Del Genio CI, Harrison F. A case study of the Ancientbiotics collaboration. Patterns (N Y). 2022 Dec 9;3(12):100632.

2. https://www.nottingham.ac.uk/news/pressreleases/2015/march/ancientbiotics---a-medieval-remedy-for-modern-day-superbugs.aspx

3. Harrison F, Roberts AE, Gabrilska R, Rumbaugh KP, Lee C, Diggle SP. A 1,000-Year-Old Antimicrobial Remedy with Antistaphylococcal Activity. mBio. 2015 Aug 11;6(4):e01129.

4. Dalton T, Dowd SE, Wolcott RD, Sun Y, Watters C, Griswold JA, Rumbaugh KP. An in vivo polymicrobial biofilm wound infection model to study interspecies interactions. PLoS One. 2011;6(11):e27317.

5. Furner-Pardoe J, Anonye BO, Cain R, Moat J, Ortori CA, Lee C, Barrett DA, Corre C, Harrison F. Anti-biofilm efficacy of a medieval treatment for bacterial infection requires the combination of multiple ingredients. Sci Rep. 2020 Jul 28;10(1):12687.

6. Rémy B, Mion S, Plener L, Elias M, Chabrière E, Daudé D. Interference in Bacterial Quorum Sensing: A Biopharmaceutical Perspective. Front Pharmacol. 2018 Mar 7;9:203.

7. Anonye BO, Nweke V, Furner-Pardoe J, Gabrilska R, Rafiq A, Ukachukwu F, Bruce J, Lee C, Unnikrishnan M, Rumbaugh KP, Snyder LAS, Harrison F. The safety profile of Bald's eyesalve for the treatment of bacterial infections. Sci Rep. 2020 Oct 15;10(1):17513.

Kan vitaminer och mineraler hålla dig ung?

1. “Cardiovascular mortality and N-terminal-proBNP reduced after combined selenium and coenzyme Q10 supplementation: A 5-year prospective randomized double-blind placebo-controlled trial among elderly Swedish citizens”

International Journal of Cardiology, 2013

2. ”The Effect of Coenzyme Q10 on Morbidity and Mortality in Chronic Heart Failure: Results From Q-SYMBIO: A Randomized Double-Blind Trial”

JACC, Heart Failure, 2014

3. “Selenium and Coenzyme Q10 Intervention Prevents Telomere Attrition, with Association to Reduced Cardiovascular Mortality—Sub-Study of a Randomized Clinical Trial”

Nutrients, 2022

4. “Association of dietary selenium intake with telomere length I middle-aged and older adults”

Clinical Nutrition, januari 2020

Bison och syrsor på menyn – ”Smakar som en discokula i skogen”

1. Food as a Catalyst for Change, en föreläsning arrangerad av The Peace Research Institute Oslo (PRIO), 5 Sep 2022. https://www.prio.org/events/8964

2. Kormann C. How Owamni Became the Best New Restaurant in the United States. The New Yorker, 2022-11-12. https://www.newyorker.com/magazine/2022/09/19/how-owamni-became-the-best-new-restaurant-in-the-united-states

3. U.S. Department of Health & Human Services. Diabetes and American Indians/Alaska Natives

https://minorityhealth.hhs.gov/diabetes-and-american-indiansalaska-natives Hämtad 2024-02-13.

4. U.S. Department of Health & Human Services. Heart Disease and American Indians/Alaska Natives.

https://minorityhealth.hhs.gov/heart-disease-and-american-indiansalaska-natives Hämtad 2024-02-13.

Glycin och NAC för hälsosamt åldrande

1. Kumar P, Liu C, Suliburk J, Hsu JW, Muthupillai R, Jahoor F, Minard CG, Taffet GE, Sekhar RV. Supplementing Glycine and N-Acetylcysteine (GlyNAC) in Older Adults Improves Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Physical Function, and Aging Hallmarks: A Randomized Clinical Trial. J Gerontol A Biol Sci Med Sci. 2023 Jan 26;78 (1):75-89.

2. Nguyen D, Samson SL, Reddy VT, Gonzalez EV, Sekhar RV. Impaired mitochondrial fatty acid oxidation and insulin resistance in aging: novel protective role of glutathione. Aging Cell. 2013 Jun;12(3):415-25.

3. Meléndez-Hevia E, De Paz-Lugo P, Cornish-Bowden A, Cárdenas ML. A weak link in metabolism: the metabolic capacity for glycine biosynthesis does not satisfy the need for collagen synthesis. J Biosci. 2009 Dec;34(6):853-72.

4. Razak MA, Begum PS, Viswanath B, Rajagopal S. Multifarious Beneficial Effect of Nonessential Amino Acid, Glycine: A Review. Oxid Med Cell Longev. 2017;2017:1716701.

5. Kawai N, Sakai N, Okuro M, Karakawa S, Tsuneyoshi Y, Kawasaki N, Takeda T, Bannai M, Nishino S. The sleep-promoting and hypothermic effects of glycine are mediated by NMDA receptors in the suprachiasmatic nucleus. Neuropsychopharmacology. 2015 May;40(6):1405-16.

6. Alves A, Bassot A, Bulteau AL, Pirola L, Morio B. Glycine Metabolism and Its Alterations in Obesity and Metabolic Diseases. Nutrients. 2019 Jun 16;11(6):1356.

7. Oliver G, Dean O, Camfield D, Blair-West S, Ng C, Berk M, Sarris J. N-acetyl cysteine in the treatment of obsessive compulsive and related disorders: a systematic review. Clin Psychopharmacol Neurosci. 2015 Apr 30;13(1):12-24.

8. Liu YJ, Janssens GE, McIntyre RL, Molenaars M, Kamble R, Gao AW, Jongejan A, Weeghel MV, MacInnes AW, Houtkooper RH. Glycine promotes longevity in Caenorhabditis elegans in a methionine cycle-dependent fashion. PLoS Genet. 2019 Mar 7;15(3):e1007633.

9. Oh SI, Park JK, Park SK. Lifespan extension and increased resistance to environmental stressors by N-acetyl-L-cysteine in Caenorhabditis elegans. Clinics (Sao Paulo). 2015 May;70(5):380-6.

10. Kumar P, Osahon OW, Sekhar RV. GlyNAC (Glycine and N-Acetylcysteine) Supplementation in Mice Increases Length of Life by Correcting Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Abnormalities in Mitophagy and Nutrient Sensing, and Genomic Damage. Nutrients. 2022 Mar 7;14(5):1114.

11. Lizzo G, Migliavacca E, Lamers D, Frézal A, Corthesy J, Vinyes-Parès G, Bosco N, Karagounis LG, Hövelmann U, Heise T, von Eynatten M, Gut P. A Randomized Controlled Clinical Trial in Healthy Older Adults to Determine Efficacy of Glycine and N-Acetylcysteine Supplementation on Glutathione Redox Status and Oxidative Damage. Front Aging. 2022 Mar 7;3:852569.

12. Baylor College of Medicine. GlyNAC supplementation reverses aging hallmarks in aging humans. Pressmeddelande 2022-08-17. https://www.bcm.edu/news/glynac-supplementation-reverses-aging-hallmarks-in-aging-humans

Ökad fertilitet med ubiquinol Q10?

1. SCB, Utan barn – skillnader i barnlöshet mellan kvinnor och män i olika grupper Demografiska rapporter 2020:1 Utan barn (scb.se)

2. Bhagavan HN, Chopra RK. Plasma coenzyme Q10 response to oral ingestion of coenzyme Q10 formulations. Mitochondrion. 2007 Jun;7 Suppl:S78-88. Plasma coenzyme Q10 response to oral ingestion of coenzyme Q10 formulations - PubMed (nih.gov)

3. Babayev E, Seli E. Oocyte mitochondrial function and reproduction. Curr Opin Obstet Gynecol. 2015 Jun;27(3):175-81. Oocyte mitochondrial function and reproduction - PMC (nih.gov)

4. Pizzorno J. Mitochondria-Fundamental to Life and Health. Integr Med (Encinitas). 2014 Apr;13(2):8-15. Mitochondria—Fundamental to Life and Health - PMC (nih.gov)

5. May-Panloup P et al. Embryo and Its Mitochondria. Antioxidants (Basel). 2021 Jan 20;10(2):139. Embryo and Its Mitochondria - PMC (nih.gov)

6. Ben-Meir A et al. Coenzyme Q10 restores oocyte mitochondrial function and fertility during reproductive aging. Aging Cell. 2015 Oct;14(5):887-95. Coenzyme Q10 restores oocyte mitochondrial function and fertility during reproductive aging - PubMed (nih.gov)

7. Bonomi M et al. Blood cell mitochondrial DNA content and premature ovarian aging. PLoS One. 2012;7(8):e42423. Blood Cell Mitochondrial DNA Content and Premature Ovarian Aging - PMC (nih.gov)

8. Thakur AS et al. Effect of Ubiquinol on Serum Reproductive Hormones of Amenorrhic Patients. Indian J Clin Biochem. 2016 Jul;31(3):342-8. Effect of Ubiquinol on Serum Reproductive Hormones of Amenorrhic Patients - PMC (nih.gov)

9. Xu Y et al. Pretreatment with coenzyme Q10 improves ovarian response and embryo quality in low-prognosis young women with decreased ovarian reserve: a randomized controlled trial. Reprod Biol Endocrinol. 2018 Mar 27;16(1):29. Pretreatment with coenzyme Q10 improves ovarian response and embryo quality in low-prognosis young women with decreased ovarian reserve: a randomized controlled trial - PMC (nih.gov)

10. Ozdemir A et al. (2019) Antioxidant Supplement Improves the Pregnancy Rate in Patients Undergoing in Vitro Fertilization for Unexplained Infertility. Open Journal of Obstetrics and Gynecology, 9, 1-9. Antioxidant Supplement Improves the Pregnancy Rate in Patients Undergoing in Vitro Fertilization for Unexplained Infertility (scirp.org)

11. Hosoe K et al. Study on safety and bioavailability of ubiquinol (Kaneka QH) after single and 4-week multiple oral administration to healthy volunteers. Regul Toxicol Pharmacol. 2007 Feb;47(1):19-28. Study on safety and bioavailability of ubiquinol (Kaneka QH) after single and 4-week multiple oral administration to healthy volunteers - PubMed (nih.gov)

12. Ikematsu H et al. Safety assessment of coenzyme Q10 (Kaneka Q10) in healthy subjects: a double-blind, randomized, placebo-controlled trial. Regul Toxicol Pharmacol. 2006 Apr;44(3):212-8. Safety assessment of coenzyme Q10 (Kaneka Q10) in healthy subjects: a double-blind, randomized, placebo-controlled trial - PubMed (nih.gov)

13. Zhang Y et al. Ubiquinol is superior to ubiquinone to enhance Coenzyme Q10 status in older men. Food Funct. 2018 Nov 14;9(11):5653-5659. Ubiquinol is superior to ubiquinone to enhance Coenzyme Q10 status in older men - PubMed (nih.gov)

14. García-Corzo L et al. Ubiquinol-10 ameliorates mitochondrial encephalopathy associated with CoQ deficiency. Biochim Biophys Acta. 2014 Jul;1842(7):893-901. Ubiquinol-10 ameliorates mitochondrial encephalopathy associated with CoQ deficiency - PubMed (nih.gov)

Kan vi hålla oss unga med Q10 och selen?

1.Alehagen U, Johansson P, Björnstedt M, Rosén A, Dahlström U. Cardiovascular mortality and N-terminal-proBNP reduced after combined selenium and coenzyme Q10 supplementation: a 5-year prospective randomized double-blind placebo-controlled trial among elderly Swedish citizens. Int J Cardiol. 2013 Sep 1;167(5):1860-6.

2. Mortensen SA, Rosenfeldt F, Kumar A, Dolliner P, Filipiak KJ, Pella D, Alehagen U, Steurer G, Littarru GP; Q-SYMBIO Study Investigators. The effect of coenzyme Q10 on morbidity and mortality in chronic heart failure: results from Q-SYMBIO: a randomized double-blind trial. JACC Heart Fail. 2014 Dec;2(6):641-9.

3. Opstad TB, Alexander J, Aaseth JO, Larsson A, Seljeflot I, Alehagen U. Selenium and Coenzyme Q10Intervention Prevents Telomere Attrition, with Association to Reduced Cardiovascular Mortality-Sub-Study of a Randomized Clinical Trial. Nutrients. 2022 Aug 15;14(16):3346.

4. Shu Y, Wu M, Yang S, Wang Y, Li H. Association of dietary selenium intake with telomere length in middle-aged and older adults. Clin Nutr. 2020 Oct;39(10):3086-3091.

Sköldkörteln behöver selen

1. Effect of levothyroxine sodium combined

with selenium supplement.International Journal of Clinical and Experimental Medicine, 2020;13(7):4695-4703

2. Derumeaux H, Valeix P, Castetbon K, Bensimon M, Boutron-Ruault MC, Arnaud J, Hercberg S. Association of selenium with thyroid volume and echostructure in 35- to 60-year-old French adults. Eur J Endocrinol. 2003 Mar;148(3):309-15. 3 Alehagen U, Johansson P, Björnstedt M, Rosén A, Dahlström U. Cardiovascular mortality and N-terminal-proBNP reduced after combined selenium and coenzyme Q10 supplementation: a 5-year prospective randomized double-blind placebo-controlled trial among elderly Swedish citizens. Int J Cardiol. 2013 Sep 1;167(5):1860-6. 4 Outzen M, Tjønneland A, Larsen EH, Andersen KK, Christensen J, Overvad K, Olsen A. The effect on selenium concentrations of a randomized intervention with fish and mussels in a population with relatively low habitual dietary selenium intake. Nutrients. 2015 Jan 15;7(1):608-24.

Avokado ger bättre hud

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3664913/

Nr 3, 2023: Starkare och friskare lungor

Ta hand om tarmen – skydda dina lungor:

1. Caffaratti C, Plazy C, Mery G, Tidjani AR, Fiorini F, Thiroux S, Toussaint B, Hannani D, Le Gouellec A. What We Know So Far about the Metabolite-Mediated Microbiota-Intestinal Immunity Dialogue and How to Hear the Sound of This Crosstalk. Metabolites. 2021 Jun 21;11(6):406.

2. Zhang F, Lau RI, Liu Q, Su Q, Chan FKL, Ng SC. Gut microbiota in COVID-19: key microbial changes, potential mechanisms and clinical applications. Nat Rev Gastroenterol Hepatol. 2023 May;20(5):323-337.

3. Ni S, Yuan X, Cao Q, Chen Y, Peng X, Lin J, Li Y, Ma W, Gao S, Chen D. Gut microbiota regulate migration of lymphocytes from gut to lung. Microb Pathog. 2023 Aug 23;183:106311.

4. Bowerman KL, Rehman SF, Vaughan A, Lachner N, Budden KF, Kim RY, Wood DLA, Gellatly SL, Shukla SD, Wood LG, Yang IA, Wark PA, Hugenholtz P, Hansbro PM. Disease-associated gut microbiome and metabolome changes in patients with chronic obstructive pulmonary disease. Nat Commun. 2020 Nov 18;11(1):5886.

5. Demirci, M. et al. Reduced Akkermansia muciniphila and Faecalibacterium prausnitzii levels in the gut microbiota of children with allergic asthma. Allergol. Immunopathol. 47, 365–371 (2019).

6. Trompette, A. et al. Dietary fiber confers protection against flu by shaping Ly6c(−) patrolling monocyte hematopoiesis and CD8(+) T cell metabolism. Immunity. 2018;48:992–1005. e1008.

7. Spacova I, Van Beeck W, Seys S, Devos F, Vanoirbeek J, Vanderleyden J, Ceuppens J, Petrova M, Lebeer S. Lactobacillus rhamnosus probiotic prevents airway function deterioration and promotes gut microbiome resilience in a murine asthma model. Gut Microbes. 2020 Nov 1;11(6):1729-1744.

8. Xie Q, Yuan J, Wang Y. Treating asthma patients with probiotics: a systematic review and meta-analysis. Nutr Hosp. 2023 Aug 28;40(4):829-838. English.

9. Wawryk-Gawda E, Markut-Miotła E, Emeryk A. Postnatal probiotics administration does not prevent asthma in children, but using prebiotics or synbiotics may be the effective potential strategies to decrease the frequency of asthma in high-risk children - a meta-analysis of clinical trials. Allergol Immunopathol (Madr). 2021 Jul 1;49(4):4-14.

10.Haberman, Y., Kamer, I., Amir, A. et al. Gut microbial signature in lung cancer patients highlights specific taxa as predictors for durable clinical benefit. Sci Rep 13, 2007 (2023).

11.Jin C, Lagoudas GK, Zhao C, Bullman S, Bhutkar A, Hu B, Ameh S, Sandel D, Liang XS, Mazzilli S, Whary MT, Meyerson M, Germain R, Blainey PC, Fox JG, Jacks T. Commensal Microbiota Promote Lung Cancer Development via γδ T Cells. Cell. 2019 Feb 21;176(5):998-1013.e16.

12.Liu X, Cheng Y, Zang D, Zhang M, Li X, Liu D, Gao B, Zhou H, Sun J, Han X, Lin M, Chen J. The Role of Gut Microbiota in Lung Cancer: From Carcinogenesis to Immunotherapy. Front Oncol. 2021 Aug 19;11:720842.

13.Tsay, T. B., Yang, M. C., Chen, P. H., Hsu, C. M. & Chen, L. W. Gut flora enhance bacterial clearance in lung through toll-like receptors 4. J. Biomed. Sci. 2011;18:68.

14.Ichinohe, T. et al. Microbiota regulates immune defense against respiratory tract influenza A virus infection. Proc. Natl Acad. Sci. USA. 2011;108:5354–5359.

15.Sencio V, Machado MG, Trottein F. The lung-gut axis during viral respiratory infections: the impact of gut dysbiosis on secondary disease outcomes. Mucosal Immunol. 2021 Mar;14(2):296-304. doi: 10.1038/s41385-020-00361-8. Epub 2021 Jan 26. PMID: 33500564; PMCID: PMC7835650.

16.Boucher E, Plazy C, Le Gouellec A, Toussaint B, Hannani D. Inulin Prebiotic Protects against Lethal Pseudomonas aeruginosa Acute Infection via γδ T Cell Activation. Nutrients. 2023 Jul 5;15(13):3037. doi: 10.3390/nu15133037. PMID: 37447363; PMCID: PMC10346238.

17.Kim Y.J., Lee J.Y., Lee J.J., Jeon S.M., Silwal P., Kim I.S., Kim H.J., Park C.R., Chung C., Han J.E., et al. Arginine-Mediated Gut Microbiome Remodeling Promotes Host Pulmonary Immune Defense against Nontuberculous Mycobacterial Infection. Gut Microbes. 2022;14:2073132.

18.Zhang F, Lau RI, Liu Q, Su Q, Chan FKL, Ng SC. Gut microbiota in COVID-19: key microbial changes, potential mechanisms and clinical applications. Nat Rev Gastroenterol Hepatol. 2023 May;20(5):323-337. doi: 10.1038/s41575-022-00698-4. Epub 2022 Oct 21. Erratum in: Nat Rev Gastroenterol Hepatol. 2023 Mar;20(3):195.

Miljögifter:

Fenton, S. E., Ducatman, A., Boobis, A., DeWitt, J. C., Lau, C., Ng, C., Smith, J. S., Roberts, S. M. Per- and Polyfluoroalkyl Substance Toxicity and Human Health Review: Current State of Knowledge and Strategies for Informing Future Research. Environmental toxicology and chemistry. 2021;40(3):606–630.

2. Eve L, Fervers B, Le Romancer M, Etienne-Selloum N. Int J Mol Sci. 2020;21(23):9139.

3. Montero-Montoya R, López-Vargas R, Arellano-Aguilar O. Volatile Organic Compounds in Air: Sources, Distribution, Exposure and Associated Illnesses in Children. Ann Glob Health. 2018;84(2):225-238. Published 2018 Jul 27.

4. Balali-Mood M, Naseri K, Tahergorabi Z, Khazdair MR, Sadeghi M. Toxic Mechanisms of Five Heavy Metals: Mercury, Lead, Chromium, Cadmium, and Arsenic. Front Pharmacol. 2021;12:643972.

5. Hodges RE, Minich DM. Modulation of Metabolic Detoxification Pathways Using Foods and Food-Derived Components: A Scientific Review with Clinical Application. J Nutr Metab. 2015;2015:760689.

6. Baer-Dubowska, W., Szaefer, H.Modulation of carcinogen-metabolizing cytochromes P450 by phytochemicals in humans. Expert opinion on drug metabolism & toxicology 2013;9(8): 927–941.

7. Walters, D. G., Young, P. J., Agus, C., Knize, M. G., Boobis, A. R., Gooderham, N. J., & Lake, B. G. Cruciferous vegetable consumption alters the metabolism of the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in humans. Carcinogenesis 2004;25(9): 1659–1669.

8. Fahey JW, Zhang Y, Talalay P. Broccoli sprouts: an exceptionally rich source of inducers of enzymes that protect against chemical carcinogens. Proc Natl Acad Sci U S A. 1997;94(19):10367-10372.

9. Kleszczyński, K., Ernst, I. M., Wagner, A. E., Kruse, N., Zillikens, D., Rimbach, G., Fischer, T. W. Sulforaphane and phenylethyl isothiocyanate protect human skin against UVR-induced oxidative stress and apoptosis: role of Nrf2-dependent gene expression and antioxidant enzymes. Pharmacological research 2013;78: 28–40.

10. Riedl MA, Saxon A, Diaz-Sanchez D. Oral sulforaphane increases Phase II antioxidant enzymes in the human upper airway. Clin Immunol. 2009;130(3):244-251.

11. Egner, P. A., Chen, J. G., Zarth, A. T., Ng, D. K., Wang, J. B., Kensler, K. H., Jacobson, L. P., Muñoz, A., Johnson, J. L., Groopman, J. D., Fahey, J. W., Talalay, P., Zhu, J., Chen, T. Y., Qian, G. S., Carmella, S. G., Hecht, S. S., Kensler, T. W. Rapid and sustainable detoxication of airborne pollutants by broccoli sprout beverage: results of a randomized clinical trial in China. Cancer prevention research (Philadelphia, Pa.) 2014; 7(8): 813–823.

12. Wu, G., Fang, Y. Z., Yang, S., Lupton, J. R., & Turner, N. D. Glutathione metabolism and its implications for health. The Journal of nutrition 2004;134(3): 489–492.

13. Richie, J. P., Jr, Nichenametla, S., Neidig, W., Calcagnotto, A., Haley, J. S., Schell, T. D., Muscat, J. E. . Randomized controlled trial of oral glutathione supplementation on body stores of glutathione. European journal of nutrition. 2015;54(2): 251–263.

14. Burns J, Yokota T, Ashihara H, Lean ME, Crozier A.. Plant foods and herbal sources of resveratrol. Journal of agricultural and food chemistry. 2002;50(11): 3337–3340.

15. Chow HH, Garland LL, Hsu CH, et al. Resveratrol modulates drug- and carcinogen-metabolizing enzymes in a healthy volunteer study. Cancer Prev Res (Phila). 2010;3(9):1168-1175.

16. Kode A, Rajendrasozhan S, Caito S, Yang SR, Megson, IL, Rahman I. Resveratrol induces glutathione synthesis by activation of Nrf2 and protects against cigarette smoke-mediated oxidative stress in human lung epithelial cells. American journal of physiology. Lung cellular and molecular physiology. 2008;294(3): L478–L488.

17. Minich DM, Brown BI. A Review of Dietary (Phyto)Nutrients for Glutathione Support. Nutrients. 2019;11(9):2073.

18. Misra UK, Kalita J, Singh, S K, Rahi, S K. Oxidative Stress Markers in Vitamin B12 Deficiency. Molecular neurobiology, 2017;54(2), 1278–1284.

Adaptogena örter för ökad lunghälsa:

1. Bruce J, Oyedemi B, Parsons N, Harrison F. Phase 1 safety trial of a natural product cocktail with antibacterial activity in human volunteers. Sci Rep. 2022 Nov 16;12(1):19656.

2. Silveira D, Prieto-Garcia JM, Boylan F, Estrada O, Fonseca-Bazzo YM, Jamal CM, Magalhães PO, Pereira EO, Tomczyk M, Heinrich M. COVID-19: Is There Evidence for the Use of Herbal Medicines as Adjuvant Symptomatic Therapy? Front Pharmacol. 2020 Sep 23;11:581840.

3. Prajapati SK, Malaiya A, Mishra G, Jain D, Kesharwani P, Mody N, Ahmadi A, Paliwal R, Jain A. An exhaustive comprehension of the role of herbal medicines in Pre- and Post-COVID manifestations. J Ethnopharmacol. 2022 Oct 5;296:115420.

4. Panossian A. Understanding adaptogenic activity: specificity of the pharmacological action of adaptogens and other phytochemicals. Ann N Y Acad Sci. 2017;1401:49–64.

5. Panossian A, Brendler T. The Role of Adaptogens in Prophylaxis and Treatment of Viral Respiratory Infections. Pharmaceuticals (Basel). 2020 Sep 8;13(9):236.

6. Panossian A, Wikman G. Effects of Adaptogens on the Central Nervous System and the Molecular Mechanisms Associated with Their Stress-Protective Activity. Pharmaceuticals (Basel). 2010 Jan 19;3(1):188-224.

7. Liao LY, He YF, Li L, Meng H, Dong YM, Yi F, Xiao PG. A preliminary review of studies on adaptogens: comparison of their bioactivity in TCM with that of ginseng-like herbs used worldwide. Chin Med. 2018 Nov 16;13:57.

8. Panossian A, Efferth T. Network Pharmacology of Adaptogens in the Assessment of Their Pleiotropic Therapeutic Activity. Pharmaceuticals (Basel). 2022 Aug 25;15(9):1051.

9. Panossian A. Challenges in phytotherapy research. Front Pharmacol. 2023 May 31;14:1199516.

10.Panossian A, Brendler T. The Role of Adaptogens in Prophylaxis and Treatment of Viral Respiratory Infections. Pharmaceuticals (Basel). 2020 Sep 8;13(9):236.

11.NIH. Health information. Asian ginseng. https://www.nccih.nih.gov/health/asian-ginseng

12.Gomaa AA, Abdel-Wadood YA. The potential of glycyrrhizin and licorice extract in combating COVID-19 and associated conditions. Phytomed Plus. 2021 Aug;1(3):100043.

13.Chuang ML, Wu TC, Wang YT, Wang YC, Tsao TC, Wei JC, Chen CY, Lin IF. Adjunctive Treatment with Rhodiola Crenulata in Patients with Chronic Obstructive Pulmonary Disease--A Randomized Placebo Controlled Double Blind Clinical Trial. PLoS One. 2015 Jun 22;10(6):e0128142.

14.Ratiani L, Pachkoria E, Mamageishvili N, Shengelia R, Hovhannisyan A, Panossian A. Efficacy of Kan Jang® in Patients with Mild COVID-19: A Randomized, Quadruple-Blind, Placebo-Controlled Trial. Pharmaceuticals (Basel). 2023 Aug 22;16(9):1196.

Nr 2, 2023: Svampar - de goda och de onda

Svamparnas läkande kraft:

1. Gründemann C, Reinhardt JK, Lindequist U. European medicinal mushrooms: Do they have potential for modern medicine? - An update. Phytomedicine. 2020 Jan;66:153131.

2. AMERICAN PHYSIOLOGICAL SOCIETY. Rare Chinese mushroom derivative can improve capacity, endurance, in sedentary elderly. Pressmeddelande 2004-04-19. https://www.eurekalert.org/news-releases/481021

3. Das G, Shin HS, Leyva-Gómez G, Prado-Audelo MLD, Cortes H, Singh YD, Panda MK, Mishra AP, Nigam M, Saklani S, Chaturi PK, Martorell M, Cruz-Martins N, Sharma V, Garg N, Sharma R, Patra JK. Cordyceps spp.: A Review on Its Immune-Stimulatory and Other Biological Potentials. Front Pharmacol. 2021 Feb 8;11:602364.

4. Anusiya G, Gowthama Prabu U, Yamini NV, Sivarajasekar N, Rambabu K, Bharath G, Banat F. A review of the therapeutic and biological effects of edible and wild mushrooms. Bioengineered. 2021 Dec;12(2):11239-11268.

5. Xia Y, Wang D, Li J, Chen M, Wang D, Jiang Z, Liu B. Compounds purified from edible fungi fight against chronic inflammation through oxidative stress regulation. Front Pharmacol. 2022 Sep 9;13:974794.

6. Stier H, Ebbeskotte V, Gruenwald J. Immune-modulatory effects of dietary Yeast Beta-1,3/1,6-D-glucan. Nutr J. 2014 Apr 28;13:38.

7. Bains A, Chawla P, Kaur S, Najda A, Fogarasi M, Fogarasi S. Bioactives from mushroom: health attributes and food industry applications. Materials. 2021;14:247640.

8. De Marco Castro E, Calder PC, Roche HM. β-1,3/1,6-glucans and immunity: state of the art and future directions. Mol Nutr Food Res.2021;65:1901071.

9. Bashir KMI, Choi JS. Clinical and Physiological Perspectives of β-Glucans: The Past, Present, and Future. Int J Mol Sci. 2017 Sep 5;18(9):1906.

10. Egra S, Kussuma IW, Arung E, Kuspradini H. The potential of white-oyster mushroom (Pleurotus ostreatus) as antimicrobial and natural antioxidant. Biofarmasi J Nat Prod Biochem. 2019;17:102.

11. Kalaras MD, Richie JP, Calcagnotto A, Beelman RB. Mushrooms: A rich source of the antioxidants ergothioneine and glutathione. Food Chem. 2017 Oct 15;233:429-433.

12. Liu HM, Tang W, Wang XY, Jiang JJ, Zhang W, Wang W. Safe and Effective Antioxidant: The Biological Mechanism and Potential Pathways of Ergothioneine in the Skin. Molecules. 2023 Feb 8;28(4):1648.

13. Fu TT, Shen L. Ergothioneine as a Natural Antioxidant Against Oxidative Stress-Related Diseases. Front Pharmacol. 2022 Mar 18;13:850813.

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11 Weaver DF et al. Alzheimer's disease as an autoimmune disorder of innate immunity endogenously modulated by tryptophan metabolites. Alzheimers Dement (N Y). 2022 Apr 6;8(1):e12283.

12 Moir RD, Lathe R, Tanzi RE. The antimicrobial protection hypothesis of Alzheimer's disease. Alzheimers Dement. 2018 Dec;14(12):1602-1614.

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14 Benson D. Conversation with Dale Bredesen, MD. Integr Med (Encinitas). 2021 Oct;20(5):44-47.

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Äntligen en klinisk studie

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[1]7 Martin P, Sandström H. Föryngring inom räckhåll – så minskar du din biologiska ålder. Hälsa & Funktionsmedicin nr 2 2002.

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När östrogenet sjunker förändras hjärnan

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Nr 4, 2022: Huden

James Nestor: ”Så påverkar andningen din hälsa”

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5401711/

Atopiskt eksem och näringsmedicin: En klinisk överblick

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Huden ‒ en hel hormonfabrik som aktiveras av solsken

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Nr 3, 2022: Träning och rörelse

Precisionshälsa – framtidens friskvård är redan här

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Träning minskar giftigt ämne och skyddar mot depression

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Fyra träningsformer för bättre fysik – vilken passar dig?

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Överrörlighet och kopplingen till ångest och mag-tarmbesvär

1) Csecs JLL, Iodice V, Rae CL, Brooke A, Simmons R, Quadt L, Savage GK, Dowell NG, Prowse F, Themelis K, Mathias CJ, Critchley HD, Eccles JA. Joint Hypermobility Links Neurodivergence to Dysautonomia and Pain. Front Psychiatry. 2022 Feb 2;12:786916.

2) Patients with Ehlers-Danlos syndrome-hypermobility type (EDS-HT) have increased prevalence of gastrointestinal (GI) symptoms, particularly reflux and dyspepsia. https://pubmed.ncbi.nlm.nih.gov/27683076/

3) Sharp HEC, Critchley HD, Eccles JA. Connecting brain and body: Transdiagnostic relevance of connective tissue variants to neuropsychiatric symptom expression. World J Psychiatry. 2021 Oct 19;11(10):805-820.

4) Pailhez G, Rosado S, Bulbena Cabré A, Bulbena A. Joint hypermobility, fears, and chocolate consumption. J Nerv Ment Dis. 2011 Nov;199(11):903-6.

5) Javadi Parvaneh V, Modaress S, Zahed G, Rahmani K, Shiari R. Prevalence of generalized joint hypermobility in children with anxiety disorders. BMC Musculoskelet Disord. 2020 Jun 2;21(1):337.

6)Do T, Diamond S, Green C, Warren M. Nutritional Implications of Patients with Dysautonomia and Hypermobility Syndromes. Curr Nutr Rep. 2021 Dec;10(4):324-333.

7) Brockway L. Gastrointestinal problems in hypermobile Ehlers-Danlos syndrome and hypermobility spectrum disorders. Ehler-Danlos Support UK. https://www.ehlers-danlos.org/information/gastrointestinal-problems-in-hypermobile-ehlers-danlos-syndrome-and-hypermobility-spectrum-disorders

8) Zhou W, Zikos T, Neshatian L, Nguyen L. S0476 high prevalence of methane predominant small bowel bacterial overgrowth and constipation in patients with hypermobile Ehlers-Danlos syndrome. Off J Am Coll Gastroenterol ACG. 2020;115:S238.

Nr 2, 2022: Lust

Sjunkande testosteronnivåer – en skrämmande trend

https://pubmed.ncbi.nlm.nih.gov/17062768/
https://pubmed.ncbi.nlm.nih.gov/32081788/
https://pubmed.ncbi.nlm.nih.gov/29774504/
https://pubmed.ncbi.nlm.nih.gov/32168194/
https://pubmed.ncbi.nlm.nih.gov/28981654/
https://www.naturskyddsforeningen.se/artiklar/10-satt-att-undvika-pfas/
https://www.ewg.org/consumer-guides

Solskydd med solkig baksida

https://www.radron.se/granskningar/omstridda-solskydd-under-luppen/
https://www.dagensmedicin.se/specialistomraden/cancer/kemiska-solskydd-kan-ga-ut-i-blodet/

Den moderna hygienen, ett rent helvete

https://www.theatlantic.com/health/archive/2016/06/i-stopped-showering-and-life-continued/486314/

Föryngring inom räckhåll – så minskar du din biologiska ålder

1. Sindi S, Solomon A, Kåreholt I, Hovatta I, Antikainen R, Hänninen T, Levälahti E, Laatikainen T, Lehtisalo J, Lindström J, Paajanen T, Peltonen M, Singh Khalsa D, Wolozin B, Strandberg T, Tuomilehto J, Soininen H, Ngandu T, Kivipelto M; FINGER Study Group. Telomere Length Change in a Multidomain Lifestyle Intervention to Prevent Cognitive Decline: A Randomized Clinical Trial. J Gerontol A Biol Sci Med Sci. 2021 Feb 25;76(3):491-498.

2. Gerontological society of America. Cellular Nutrition and Its Influence on Age-Associated Cellular Decline. Nyhetsbrev nov. 2021. https://www.geron.org/images/gsa/documents/whatshotcellularnutrition.pdf Hämtad 2022-04-29

3. Gensous N, Garagnani P, Santoro A, Giuliani C, Ostan R, Fabbri C, Milazzo M, Gentilini D, di Blasio AM, Pietruszka B, Madej D, Bialecka-Debek A, Brzozowska A, Franceschi C, Bacalini MG. One-year Mediterranean diet promotes epigenetic rejuvenation with country- and sex-specific effects: a pilot study from the NU-AGE project. Geroscience. 2020 Apr;42(2):687-701.

4. Chen L, Dong Y, Bhagatwala J, Raed A, Huang Y, Zhu H. Effects of Vitamin D3 Supplementation on Epigenetic Aging in Overweight and Obese African Americans With Suboptimal Vitamin D Status: A Randomized Clinical Trial. J Gerontol A Biol Sci Med Sci. 2019 Jan 1;74(1):91-98.

5. Fitzgerald KN, Hodges R, Hanes D, Stack E, Cheishvili D, Szyf M, Henkel J, Twedt MW, Giannopoulou D, Herdell J, Logan S, Bradley R. Potential reversal of epigenetic age using a diet and lifestyle intervention: a pilot randomized clinical trial. Aging. 2021 13(7), 9419–9432.

6. Ritchie, H. The world population is changing. Our world in data, 2019-05-23. https://ourworldindata.org/population-aged-65-outnumber-children Hämtad 2022-04-29.

7. Kirkland JL, De Rooij SE, Goldman DP. Proof-of-concept clinical trials of interventions that target fundamental aging processes how can interventions be translated from the laboratory into clinical practice the economic returns to delayed aging: promise and pitfalls. Innov Aging. 2017. (Suppl 1); 1:1082.

8. Fitzgerald K. Younger You. Quercus Publishing, 2022.

Brister eller begär – kan chokladsuget bero på näringsbrist?

1) Komatsu S. Rice and sushi cravings: a preliminary study of food craving among Japanese females. Appetite. 2008;50:353–358.

2) Romaní-Pérez M, Bullich-Vilarrubias C, López-Almela I, Liébana-García R, Olivares M, Sanz Y. The Microbiota and the Gut-Brain Axis in Controlling Food Intake and Energy Homeostasis. Int J Mol Sci. 2021 May 29;22(11):5830.

3) Trevelline BK, Kohl KD. The gut microbiome influences host diet selection behavior. Proc Natl Acad Sci U S A. 2022 Apr 26;119(17):e2117537119.

4) Alcock J, Maley CC, Aktipis CA. Is eating behavior manipulated by the gastrointestinal microbiota? Evolutionary pressures and potential mechanisms. Bioessays. 2014 Oct;36(10):940-9.

5) Meule A. The Psychology of Food Cravings: the Role of Food Deprivation. Curr Nutr Rep. 2020 Sep;9(3):251-257.

Näringsstöd vid långtidscovid

[1]) Paul Garner: on his recovery from long covid. The BMJ Opinion. 2021-01-25. https://blogs.bmj.com/bmj/2021/01/25/paul-garner-on-his-recovery-from-long-covid/ Hämtad 2022-05-20.

2) Bland JS. The Long Haul of COVID-19 Recovery: Immune Rejuvenation versus Immune Support. Integr Med (Encinitas). 2020 Dec;19(6):18-22.

3) Benson D. Leo Galland, MD: Treating PASC (Post-Acute Sequelae of COVID): How to Address Long-Hauler's Syndrome Effectively. Integr Med (Encinitas). 2021 Dec;20(6):36-37.

4) Cuervo AM, Macian F. Autophagy, nutrition and immunology. Mol Aspects Med. 2012. February;33(1):2-13.

5) Shen L, Yang Y, Ou T, Key CC, Tong SH, Sequeira RC, Nelson JM, Nie Y, Wang Z, Boudyguina E, Shewale SV, Zhu X. Dietary PUFAs attenuate NLRP3 inflammasome activation via enhancing macrophage autophagy. J Lipid Res. 2017. September;58(9):1808-1821.

6) Santos JC, Ribeiro ML, Gambero A. The Impact of Polyphenols-Based Diet on the Inflammatory Profile in COVID-19 Elderly and Obese Patients. Front Physiol. 2021 Jan 12;11:612268.

Nr 1, 2022: Allergi

Födoämneskänslighet, skillnaden mellan allergi, intolerans och fördröjd allergi

[1] NIAID 2010 Guidelines J Allergy Clin Immunol. 2010 Dec;126(6 Suppl):S1-58.

[1] Bannon GA. What makes a food protein an allergen? Curr Allergy Asthma Rep. 2004 Jan;4(1):43-6.

[1] Ho MH, Wong WH, Chang C. Clinical spectrum of food allergies: a comprehensive review. Clin Rev Allergy Immunol. 2014 Jun;46(3):225-40.

[1] Dieterich W, Tietz E, Kohl M, Konturek PC, Rath T, Neurath MF, Zopf Y. Food Intolerance of Unknown Origin: Caused by Mucosal Inflammation? A Pilot Study. Clin Transl Gastroenterol. 2021 Feb 17;12(2):e00312.

[1] NIAID 2010 Guidelines J Allergy Clin Immunol. 2010 Dec;126(6 Suppl):S1-58.

[1] Zopf Y, Baenkler HW, Silbermann A, Hahn EG, Raithel M. The differential diagnosis of food intolerance. Dtsch Arztebl Int. 2009 May;106(21):359-69; quiz 369-70; 4 p following 370.

[1] Ho MH, Wong WH, Chang C. Clinical spectrum of food allergies: a comprehensive review. Clin Rev Allergy Immunol. 2014 Jun;46(3):225-40.

[1] Uhde M, Ajamian M, Caio G, De Giorgio R, Indart A, Green PH, Verna EC, Volta U, Alaedini A. Intestinal cell damage and systemic immune activation in individuals reporting sensitivity to wheat in the absence of coeliac disease. Gut. 2016 Dec;65(12):1930-1937.

[1] Uhde M, Caio G, De Giorgio R, Green PH, Volta U, Alaedini A. Subclass Profile of IgG Antibody Response to Gluten Differentiates Non-Celiac Gluten Sensitivity from Celiac Disease. Gastroenterology. 2020 Jul 20:S0016-5085(20)34992-1.

[1] Dixon HS. Treatment of delayed food allergy based on specific immunoglobulin G RAST testing. Otolaryngol Head Neck Surg. 2000 Jul;123(1 Pt 1):48-54.

[1] Kukkonen AK, Savilahti EM, Haahtela T, Savilahti E, Kuitunen M. Ovalbumin-specific immunoglobulins A and G levels at age 2 years are associated with the occurrence of atopic disorders. Clin Exp Allergy. 2011 Oct;41(10):1414-21.

[1] Bentz S, Hausmann M, Piberger H, Kellermeier S, Paul S, Held L, Falk W, Obermeier F, Fried M, Schölmerich J, Rogler G. Clinical relevance of IgG antibodies against food antigens in Crohn's disease: a double-blind cross-over diet intervention study. Digestion. 2010;81(4):252-64.

[1] Xie Y, Zhou G, Xu Y, He B, Wang Y, Ma R, Chang Y, He D, Xu C, Xiao Z. Effects of Diet Based on IgG Elimination Combined with Probiotics on Migraine Plus Irritable Bowel Syndrome. Pain Res Manag. 2019 Aug 21;2019:7890461.

[1] Aydinlar EI, Dikmen PY, Tiftikci A, Saruc M, Aksu M, Gunsoy HG, Tozun N. IgG-based elimination diet in migraine plus irritable bowel syndrome. Headache. 2013 Mar;53(3):514-25.

[1] Guo H, Jiang T, Wang J, Chang Y, Guo H, Zhang W. The value of eliminating foods according to food-specific immunoglobulin G antibodies in irritable bowel syndrome with diarrhoea. J Int Med Res. 2012;40(1):204-10.

[1] Food allergy mediated by IgG antibodies associated with migraine in adults. Arroyave Hernandez CM, Echevarria Pinto M, Hernandez Montiel HL. Rev Alerg Mex (2007); 54: 162–168.

[1] Alpay K, Ertas M, Orhan EK, Ustay DK, Lieners C, Baykan B. Diet restriction in migraine, based on IgG against foods: a clinical double-blind, randomised, cross-over trial. Cephalalgia. 2010 Jul;30(7):829-37.

[1] Geiselman JF. The Clinical Use of IgG Food Sensitivity Testing with Migraine Headache Patients: a Literature Review. Curr Pain Headache Rep. 2019 Aug 27;23(11):79.

[1] Marsh JT, Jayasena S, Gaskin F, Baumert JL, Johnson P. Thermal processing of peanut impacts detection by current analytical techniques. 2020 May;313(30).

[1] Aalberse RC, Stapel SO, Schuurman J, Rispens T. Immunoglobulin G4: an odd antibody. Clin Exp Allergy. 2009 Apr;39(4):469-77.

[1] Stapel SO, Asero R, Ballmer-Weber BK, Knol EF, Strobel S, Vieths S, Kleine-Tebbe J; EAACI Task Force. Testing for IgG4 against foods is not recommended as a diagnostic tool: EAACI Task Force Report. Allergy. 2008 Jul;63(7):793-6.

[1] NIAID 2010 Guidelines J Allergy Clin Immunol. 2010 Dec;126(6 Suppl):S1-58.

Medscape Food Allergy: What You Need to Know 11/2010; Medscape Food Allergy:

The Definitive Guide to Clinical Practice: A Reliable Approach to Diagnosis 12/2010 010

Diffusa symtom kan vara histaminintolerans

Jutel M, Akdis M, Akdis CA. Histamine, histamine receptors and their role in immune pathology. Clin Exp

Allergy. 2009 Dec;39(12):1786-800.
Maintz L, Novak N. Histamine and histamine intolerance. Am J Clin Nutr. 2007 May;85(5):1185-96.
Muñoz-Cruz S, Mendoza-Rodríguez Y, Nava-Castro KE, Yepez-Mulia L, Morales-Montor J. Gender-related effects of sex steroids on histamine release and FcεRI expression in rat peritoneal mast cells. J Immunol Res. 2015;2015:351829.
Zierau O, Zenclussen AC, Jensen F. Role of female sex hormones, estradiol and progesterone, in mast cell behavior. Front Immunol. 2012 Jun 19;3:169.
Vasiadi M, Kempuraj D, Boucher W, Kalogeromitros D, Theoharides TC. Progesterone inhibits mast cell secretion. Int J Immunopathol Pharmacol. 2006 Oct-Dec;19(4):787-94.
Bódis J, Tinneberg HR, Schwarz H, Papenfuss F, Török A, Hanf V. The effect of histamine on progesterone and estradiol secretion of human granulosa cells in serum-free culture. Gynecol Endocrinol. 1993 Dec;7(4):235-9.
Maintz L, Schwarzer V, Bieber T, van der Ven K, Novak N. Effects of histamine and diamine oxidase activities on pregnancy: a critical review. Hum Reprod Update. 2008 Sep-Oct;14(5):485-95.
Ulf Bengtsson och Nils E Eriksson (red) Förrädisk föda. Andra reviderade upplagan, Astra Zeneca 2003

https://www.mastzellaktivierung.info/downloads/foodlist/21_FoodList_EN_alphabetic_withCateg.pdf

”En allergiepidemi” Är hygienhypotesen förklaringen?

Prescott SL, et al. A global survey of changing patterns of food allergy burden in children. World Allergy Organ J. 2013;6(1):21.

Lambrecht BN, Hammad H. The immunology of the allergy epidemic and the hygiene hypothesis. Nat Immunol. 2017 Sep 19;18(10):1076-1083. doi: 10.1038/ni.3829. PMID: 28926539.
Romano-Keeler J, Weitkamp JH. Maternal influences on fetal microbial colonization and immune development. Pediatr Res. 2015 Jan;77(1-2):189-95. doi: 10.1038/pr.2014.163. Epub 2014 Oct 13. PMID: 25310759; PMCID: PMC4289016.
Ipci K, Altıntoprak N, Muluk NB, Senturk M, Cingi C. The possible mechanisms of the human microbiome in allergic diseases. Eur Arch Otorhinolaryngol. 2017 Feb;274(2):617-626. doi: 10.1007/s00405-016-4058-6. Epub 2016 Apr 26. PMID: 27115907.
Lee-Sarwar K. The farm-like effect: Rural exposures in early life, the microbiome, and asthma. J Allergy Clin Immunol. 2021 Jul;148(1):89-90. doi: 10.1016/j.jaci.2021.04.020. Epub 2021 Apr 26. PMID: 33915125.
Fleming JO, Weinstock JV. Clinical trials of helminth therapy in autoimmune diseases: rationale and findings. Parasite Immunol. 2015 Jun;37(6):277-92. doi: 10.1111/pim.12175. PMID: 25600983.
Clavel T, Gomes-Neto JC, Lagkouvardos I, Ramer-Tait AE. Deciphering interactions between the gut microbiota and the immune system via microbial cultivation and minimal microbiomes. Immunol Rev. 2017 Sep;279(1):8-22. doi: 10.1111/imr.12578. PMID: 28856739; PMCID: PMC5657458.
Trompette A, Gollwitzer ES, Yadava K, Sichelstiel AK, Sprenger N, Ngom-Bru C, Blanchard C, Junt T, Nicod LP, Harris NL, Marsland BJ. Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis. Nat Med. 2014 Feb;20(2):159-66. doi: 10.1038/nm.3444. Epub 2014 Jan 5. PMID: 24390308.
Fallon, P., Mangan, N. Suppression of TH2-type allergic reactions by helminth infection. Nat Rev Immunol 7, 220–230 (2007).
Wopereis H, Oozeer R, Knipping K, Belzer C, Knol J. The first thousand days - intestinal microbiology of early life: establishing a symbiosis. Pediatr Allergy Immunol. 2014 Aug;25(5):428-38. doi: 10.1111/pai.12232. Epub 2014 Jun 5. PMID: 24899389.

Kan allergier hos barn förebyggas?

Internetmedicin.se Födoämnesöverkänslighet. Tillgänglig på: https://www.internetmedicin.se/behandlingsoversikter/allergologi/fodoamnesoverkanslighet/ Hämtad 2022-02-22.

Institutet för miljömedicin: BAMSE-projektet. Karolinska institutet. Tillgänglig på: https://ki.se/imm/bamse-projektet Hämtad 2022-02-22.
Haahtela T. A biodiversity hypothesis. Allergy. 2019 Aug;74(8):1445-1456.
Karolinska institutet. Medicinvetarna #64: Kan allergi botas? Poddsändning. Tillgänglig på: https://ki.se/forskning/medicinvetarna-64-kan-allergi-botasHämtad 2022-02-22.
Sdona E, Hallberg J, Andersson N, et al. Dietary antioxidant intake in school age and lung function development up to adolescence. Eur Respir J. 2020;55(2):1900990.
Magnusson J, Kull I, Rosenlund H, Håkansson N, Wolk A, Melén E, Wickman M, Bergström A. Fish consumption in infancy and development of allergic disease up to age 12 y. Am J Clin Nutr. 2013 Jun;97(6):1324-30.
Magnusson J, Kull I, Westman M, Håkansson N, Wolk A, Melén E, Wickman M, Bergström A. Fish and polyunsaturated fat intake and development of allergic and nonallergic rhinitis. J Allergy Clin Immunol. 2015 Nov;136(5):1247-53.e1-2.
Vickery BP, Vereda A, Nilsson C, du Toit G, Shreffler WG, Burks AW, Jones SM, Fernández-Rivas M, Blümchen K, O'B Hourihane J, Beyer K, Smith A, Ryan R, Adelman DC. Continuous and Daily Oral Immunotherapy for Peanut Allergy: Results from a 2-Year Open-Label Follow-On Study. J Allergy Clin Immunol Pract. 2021 May;9(5):1879-1889.e14.

Nr 4, 2021: Trötthet

Lustmördar gamla folkhälsosanningar med glädje, evidens och humor

[1] Toledo E, Salas-Salvadó J, Donat-Vargas C, Buil-Cosiales P, Estruch R, Ros E, Corella D, Fitó M, Hu FB, Arós F, Gómez-Gracia E, Romaguera D, Ortega-Calvo M, Serra-Majem L, Pintó X, Schröder H, Basora J, Sorlí JV, Bulló M, Serra-Mir M, Martínez-González MA. Mediterranean Diet and Invasive Breast Cancer Risk Among Women at High Cardiovascular Risk in the PREDIMED Trial: A Randomized Clinical Trial. JAMA Intern Med. 2015 Nov;175(11):1752-1760.

Kardiologen som vägrar sockra sanningen

[1] Mayo Clinic. Mediterranean diet for heart health. Bloggartikel, 2021-07-23.

https://www.mayoclinic.org/healthy-lifestyle/nutrition-and-healthy-eating/in-depth/mediterranean-diet/art-20047801

[2] Diamond DM, Alabdulgader AA, de Lorgeril M, Harcombe Z, Kendrick M, Malhotra A, O'Neill B, Ravnskov U, Sultan S, Volek JS. Dietary Recommendations for Familial Hypercholesterolaemia: an Evidence-Free Zone. BMJ Evid Based Med. 2020 Jul 5:bmjebm-2020-111412.

[3] Ebbeling CB, Knapp A, Johnson A, Wong JMW, Greco KF, Ma C, Mora S, Ludwig DS. Effects of a low-carbohydrate diet on insulin-resistant dyslipoproteinemia-a randomized controlled feeding trial. Am J Clin Nutr. 2021 Sep 28:nqab287.

Varför är jag så trött?

Malaguarnera M, Gargante MP, Cristaldi E, Colonna V, Messano M, Koverech A, Neri S, Vacante M, Cammalleri L, Motta M. Acetyl L-carnitine (ALC) treatment in elderly patients with fatigue. Arch Gerontol Geriatr. 2008 Mar-Apr;46(2):181-90

Dignar du under kognitiv belastning? Zoomtrötthet nytt forskningsämne

1) Fauville G et al. Nonverbal Mechanisms Predict Zoom Fatigue and Explain Why Women Experience Higher Levels than Men. Göteborgs universitet, 2021.

2) Bailenson JN. Nonverbal Overload: A Theoretical Argument for the Causes of Zoom Fatigue, Jeremy Bailenson, Stanford University. Technology, Mind and Behavior 2021;2(1).

3) Four reasons you’re tired of Zoom calls — and what to do about it. Washington Post 3 mars 2021. https://www.washingtonpost.com/lifestyle/2021/03/03/stanford-zoom-fatigue/

4) Global Gender Gap Report 2021, World Economic Forum, www.weforum.org.

5) Hallman DM, Januario LB, Mathiassen SE, Heiden M, Svensson S, Bergström G. Working from home during the COVID-19 outbreak in Sweden: effects on 24-h time-use in office workers. BMC Public Health. 2021 Mar 17;21(1):528.

Siesta bra för hjärtat – men tuppluren är lurig

1.Poulimenos L, Kallistratos M, Tsinivizov P, Kouremenos N, Kontogiannis N et al. Mid-day Sleep Effects as Potent as Recommended Lifestyle Changes in Patients With Arterial Hypertension. J Am Coll Cardiol. 2019 Mar, 73 (9_Supplement_2) 20

2. KecklundG, Ingre M, Åkerstedt T. Arbetstider, hälsa och säkerhet – en uppdatering av aktuell forskning. Stressforskningsrapport nr 322, Stressforskningsinstitutet, Stockholms universitet 2010.

3. Stepan ME, Altmann EM, Fenn KM. Slow Wave Sleep During a Brief Nap is Related to Reduced Cognitive Deficits During Sleep Deprivation. Sleep. 2021 Jun 22:zsab152.

4. Din hjärna, säsong två: Din sömn. Programserie av Anders Hansen, svtplay.se.

Näringen du behöver för att bilda energi

1) Tardy AL, Pouteau E, Marquez D, Yilmaz C, Scholey A. Vitamins and Minerals for Energy, Fatigue and Cognition: A Narrative Review of the Biochemical and Clinical Evidence. Nutrients. 2020 Jan 16;12(1):228. 2) Woolf K, Manore MM. B-vitamins and exercise: does exercise alter requirements? Int J Sport Nutr Exerc Metab. 2006 Oct;16(5):453-84.

3) Castro-Marrero J, Segundo MJ, Lacasa M, Martinez-Martinez A, Sentañes RS, Alegre-Martin J. Effect of Dietary Coenzyme Q10 Plus NADH Supplementation on Fatigue Perception and Health-Related Quality of Life in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Prospective, Randomized, Double-Blind, Placebo-Controlled Trial. Nutrients. 2021 Jul 30;13(8):2658.

Snabb diagnos är A och O vid ME/CFS

Källa: www.viss.nu

Kaffe: Hälsoboost eller hälsobov?

Brice CF, Smith AP. Effects of caffeine on mood and performance: a study of realistic consumption. Psychopharmacology (Berl). 2002 Nov;164(2):188-92.

Doherty M, Smith PM. Effects of caffeine ingestion on exercise testing: a meta-analysis. Int J Sport Nutr Exerc Metab. 2004 Dec;14(6):626-46.
Lara B, Ruiz-Moreno C, Salinero JJ, Del Coso J. Time course of tolerance to the performance benefits of caffeine. PLoS One. 2019 Jan 23;14(1):e0210275.
Oseguera-Castro KY, Madrid JA , Martínez Madrid MJ, García OP, Del Castillo, Campos-Vega R. Antioxidant dietary fiber isolated from spent coffee (Coffea arabica L.) grounds improves chronotype and circadian locomotor activity in young adults. Food Funct. 2019 Aug 1;10(8):4546-4556.
Maia L, de Mendonça A. Does caffeine intake protect from Alzheimer's disease? Eur J Neurol. 2002 Jul;9(4):377-82.
Nerurkar PV, Gandhi K, Chen JJ. Correlations between Coffee Consumption and Metabolic Phenotypes, Plasma Folate, and Vitamin B12: NHANES 2003 to 2006. Nutrients. 2021;13(4):1348.
Rapuri PB, Gallagher JC, Nawaz Z. Caffeine decreases vitamin D receptor protein expression and 1,25(OH)2D3 stimulated alkaline phosphatase activity in human osteoblast cells. J Steroid Biochem Mol Biol. 2007 Mar;103(3-5):368-71.
Morck TA, Lynch SR, Cook JD. Inhibition of food iron absorption by coffee. Am J Clin Nutr. 1983 Mar;37(3):416-20.
Muftic M, Selimovic EK, Miladinovic K. Osteoporosis--comparative study between quantitative ultrasound of calcaneus and DXA. Med Arch. 2013;67(4):289-91.
Naturskyddsföreningen. ”Vem betalar priset för ditt kaffe?” 2015-10-01, uppdaterad 2021-06-09.
Fredholm B. Kaffeologi, Fri Tanke, 2021.
Capili B, Anastasi JK, Chang M. Addressing the Role of Food in Irritable Bowel Syndrome Symptom Management. J Nurse Pract. 2016 May;12(5):324-329.
Melnik BC, Schmitz G. Pasteurized non-fermented cow's milk but not fermented milk is a promoter of mTORC1-driven aging and increased mortality. Ageing Res Rev. 2021 May;67:101270.

Poole R, Kennedy OJ, Roderick P, Fallowfield JA, Hayes PC, Parkes J. Coffee consumption and health: umbrella review of meta-analyses of multiple health outcomes. BMJ. 2017 Nov 22;359:j5024.

Sköldkörteln: Hur påverkar den vårt mentala välmående?

Bernal J. Thyroid hormone regulated genes in cerebral cortex development. J Endocrinol. 2017 Feb;232(2):R83-R97.

Schroeder AC, Privalsky ML. Thyroid hormones, t3 and t4, in the brain. Front Endocrinol (Lausanne). 2014 Mar 31;5:40.
Holmberg M. Outcome of Graves disease, Doktorsavhandling från Göteborgs universitet, 2020. Hämtad från:

https://gupea.ub.gu.se/handle/2077/62211?

Eslami-Amirabadi M, Sajjadi SA. The relation between thyroid dysregulation and impaired cognition/behaviour: An integrative review. J Neuroendocrinol. 2021 Mar;33(3):e12948.

Kral TRA, Imhoff-Smith T, Dean DC, Grupe D, Adluru N, Patsenko E, Mumford JA, Goldman R, Rosenkranz MA, Davidson RJ. Mindfulness-Based Stress Reduction-related changes in posterior cingulate resting brain connectivity. Soc Cogn Affect Neurosci. 2019 Jul 31;14(7):777-787.

Bettio LEB, Thacker JS, Rodgers SP, Brocardo PS, Christie BR, Gil-Mohapel J. Interplay between hormones and exercise on hippocampal plasticity across the lifespan. Biochim Biophys Acta Mol Basis Dis. 2020 Aug 1;1866(8):165821.

Carlson MC, Erickson KI, Kramer AF, Voss MW, Bolea N, Mielke M, McGill S, Rebok GW, Seeman T, Fried LP. Evidence for neurocognitive plasticity in at-risk older adults: the experience corps program. J Gerontol A Biol Sci Med Sci. 2009 Dec;64(12):1275-82.

Nr 3, 2021: Virusinfektioner

Arvet från aporna: en mutation kan vara orsaken till fetmaepidemin

1. Shapiro A, Mu W, Roncal C, Cheng KY, Johnson RJ, Scarpace PJ. Fructose-induced leptin resistance exacerbates weight gain in response to subsequent high-fat feeding. Am J Physiol Regul Integr Comp Physiol. 2008 Nov;295(5):R1370-5.

2. Perez-Pozo SE, Schold J, Nakagawa T, Sánchez-Lozada LG, Johnson RJ, Lillo JL. Excessive fructose intake induces the features of metabolic syndrome in healthy adult men: role of uric acid in the

Virus – en viktig drivkraft för människans utveckling

Enard D, Cai L, Gwennap C, Petrov DA. Viruses are a dominant driver of protein adaptation in mammals. Elife. 2016 May 17;5:e12469.

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Nilsson A. Nyfiken på virus. Medicinsk Vetenskap nr 2 2020.

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Noronha S. Viruses have big impacts on ecology and evolution as well as human health. The Economist 2020-08-20.

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Covid-19 kan orsaka autoimmun sjukdom

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3. Woodruff, Matthew C., et al. "Extrafollicular B cell responses correlate with neutralizing antibodies and morbidity in COVID-19." Nature immunology 21.12 (2020): 1506-1516.

4. Carfì, Angelo, Roberto Bernabei, and Francesco Landi. "Persistent symptoms in patients after acute COVID-19." Jama 324.6 (2020): 603-605.

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6. Lunardi, Claudio, et al. "Human parvovirus B19 infection and autoimmunity." Autoimmunity reviews 8.2 (2008): 116-120.

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9. Poole, Brian D., et al. "Epstein-Barr virus and molecular mimicry in systemic lupus erythematosus." Autoimmunity 39.1 (2006): 63-70.

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Näringsämnen som skyddar oss mot virus

Abioye A.I., Bromage S., Fawzi W. Effect of micronutrient supplements on influenza and other respiratory tract infections among adults: a systematic review and meta-analysis. BMJ Global Health. 2021:6

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Bergman P. The link between Vitamin D and Covid-19: distinguishing facts from fiction. Journal of Internal Medicine. 2020.

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Colunga Biancatelli R.M.L., Berrill M., Marik P.E. The antiviral properties of vitamin C. Expert Review of Anti-infective Therapy. 2020:18;2

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Grant W.B., Lahore H., et.al. Evidence that Vitamin D Supplementation Could Reduce Risk of Influenza and COVID-19 Infections and Deaths. Nutrients. 2020:12;4

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Hewison M. Vitamin D and the Immune System: New Perspectives on an Old Theme. Rheumatic Disease Clinics of North America. 2012:38:1

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Liang Y., Yi P., Wang B., et.al. Retinoic acid modulates hyperactive T cell responses and protects vitamin a–deficient mice against persistent lymphocytic choriomeningitis virus infection. The Journal of Immunology. 2020:204;11

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Razzaque M.S. COVID-19 Pandemic: Can Maintaining Optimal Zinc Balance Enhance Host Resistance? Tohoku Journal of Experimental Medicine. 2020:251

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Nr 2, 2021: Sömn

Drömmen om en bättre sömn

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Kopplingen mellan sömnbrist och inflammation

Aho V., Ollila H.M., Rantanen V. et al. ”Partial sleep restriction activates immune response-related gene expression pathways: experimental and epidemiological studies in humans. PLoS ONE, 2013;8.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3806729/

Benedict C., Vogel H, Jonas W. et al. Gut microbiota and glucometabolic alterations in response to recurrent partial sleep deprivation in normal-weight young individuals. Molecular Metabolism. 2016:5;12.
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https://www.hindawi.com/journals/mi/2018/9524075/

Desbonnet L., Garrett L., Clarke G. et al. The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat. Journal of Psychiatric Research. 2008:43;2.

https://www.sciencedirect.com/science/article/abs/pii/S0022395608000745

Esteban-Zubero E., López-Pingarrón L., Alatorre-Jiménez M.A., et al. Melatonin’s role as a co-adjuvant treatment in colonic diseases: A review. Life sciences. 2017:1;170.

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Heitkemper M.M., Han C.J., Jarrett M.E., Gu H. et al. Serum tryptophan metabolite levels during sleep in patients with and without irritable bowel syndrome (IBS). Biological research for nursing. 2016:18;2.

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Ritcu L.D., Padurariu M., Ciobica A. et al. Serum Cortisol Levels Modifications in Patients with Depression and Irritable Bowel Syndrome. Revista Chimie Romania. 2019:70;9.

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Smith R.P., Easson C., Lyle S.M., et al. Gut microbiome diversity is associated with sleep physiology in humans. PLoS One. 2019:14;10.

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Tu Q, Heitkemper M.M., Jarrett M.E., Buchanan D.T. Sleep disturbances in irritable bowel syndrome: a systematic review. Neurogastroenterology & Motility. 2017:29;3.

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Wirth M.D., Jessup A., Turner-McGrievy G. et al. Changes in dietary inflammatory potential predict changes in sleep quality metrics, but not sleep duration. Sleep. 2020:12;43.

https://pubmed.ncbi.nlm.nih.gov/32406919/

Yaoita F., Muto M., Murakami H., Endo S., et al. Involvement of peripheral alpha2A adrenoceptor in the acceleration of gastrointestinal transit and abdominal visceral pain induced by intermittent deprivation of REM sleep. Physiology & behavior. 2018:186.

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Så städas din hjärna när du sover

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2. Fultz, Nina E., et al. "Coupled electrophysiological, hemodynamic, and cerebrospinal fluid oscillations in human sleep." Science 366.6465 (2019): 628-631.

3. Fang, Evandro F., et al. "Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer’s disease." Nature neuroscience 22.3 (2019): 401-412.

4. Stowell, Rianne D., et al. "Noradrenergic signaling in the wakeful state inhibits microglial surveillance and synaptic plasticity in the mouse visual cortex." Nature neuroscience 22.11 (2019): 1782-1792.

Melatonin - mer än bara sömnhormon

Mukherjee S, Maitra SK. Gut Melatonin in Vertebrates: Chronobiology and Physiology. Front Endocrinol (Lausanne). 2015 Jul 22;6:112.
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Nr 1, 2021: Psykisk ohälsa

Väck kraften i din vagusnerv

Rhoades R, Tanner G, Medical Physiology : Principles for Clinical Medicine, Wolters Kluwer Health 2017.
Breit S, Kupferberg A, Rogler G, Hasler G. Vagus Nerve as Modulator of the Brain-Gut Axis in Psychiatric and Inflammatory Disorders. Front Psychiatry. 2018 Mar 13;9:44.
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Psykiatri med nytt perspektiv

[i] Volpe, SL. Magnesium in Disease Prevention and Overall Health. Advances in Nutrition, 2013 May; 4(3): 378S-383S.

[ii] Tarleton EK, at al. Magnesium Intake in Depression in Adults. Journal of the American Board of Family Medicine, 2015 Mar-Apr;28(2):249-56.

[iii] Le Noury J, Nardo JM, Healy D, Jureidini J, Raven M, Tufanaru C, Abi-Jaoude E. Restoring Study 329: efficacy and harms of paroxetine and imipramine in treatment of major depression in adolescence. BMJ. 2015 Sep 16;351:h4320.

Läckande tarm - kopplingen mellan inflammation och depression

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Kostvanor och mental hälsa - vilka är sambanden?

1Folkhälsomyndigheten Folkhälsans utveckling – årsrapport 2020

2 McCracken, Lance M., et al. "Psychological impact of COVID-19 in the Swedish population: Depression, anxiety, and insomnia and their associations to risk and vulnerability factors." European Psychiatry 63.1 (2020).

3 Mangiola, Francesca, et al. "Gut microbiota in autism and mood disorders." World journal of gastroenterology 22.1 (2016): 361.

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5 Francis, Heather M., et al. "A brief diet intervention can reduce symptoms of depression in young adults–A randomised controlled trial." PloS one 14.10 (2019): e0222768.

6Slim, Mahmoud, Fernando Rico-Villademoros, and Elena P. Calandre. "Psychiatric comorbidity in children and adults with gluten-related disorders: a narrative review." Nutrients 10.7 (2018): 875.

7 van Hees, Nathalie JM, Willem Van der Does, and Erik J. Giltay. "Coeliac disease, diet adherence and depressive symptoms." Journal of psychosomatic research 74.2 (2013): 155-160.

8Dobersek, Urska, et al. "Meat and mental health: a systematic review of meat abstention and depression, anxiety, and related phenomena." Critical Reviews in Food Science and Nutrition (2020): 1-14.

9 Craig, Winston John. "Nutrition concerns and health effects of vegetarian diets." Nutrition in Clinical Practice 25.6 (2010): 613-620.

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13 Cofnas, Nathan. "Is vegetarianism healthy for children?." Critical reviews in food science and nutrition 59.13 (2019): 2052-2060.

14 Iguacel, Isabel, et al. "Veganism, vegetarianism, bone mineral density, and fracture risk: a systematic review and meta-analysis." Nutrition reviews 77.1 (2019): 1-18.

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Litium som skydd för hjärnan

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[5] Memon A, Rogers I, Fitzsimmons SMDD, Carter B, Strawbridge R, Hidalgo-Mazzei D, Young AH. Association between naturally occurring lithium in drinking water and suicide rates: systematic review and meta-analysis of ecological studies. Br J Psychiatry. 2020 Jul 27:1-12.

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[8] Greenblatt J. Lithium: The Untold Story Of The Magic Mineral That Charges Cell Phones And Preserves Memory. Integrative medicine for mental health 2017. http://www.immh.org/article-source/2017/2/2/lithium-the-untold-story-of-the-magic-mineral-that-charges-cell-phones-and-preserves-memory

[9] Ann-Louise Gittleman. The Cinderella mineral that could defeat Alzheimer’s. Juni 2020.

[10] Choi YJ, Yoon Y, Lee KY, Kang YP, Lim DK, Kwon SW, Kang KW, Lee SM, Lee BH. Orotic acid induces hypertension associated with impaired endothelial nitric oxide synthesis. Toxicol Sci. 2015 Apr;144(2):307-17.

[11] Han X, Liu C, Xue Y, Wang J, Xue C, Yanagita T, Gao X, Wang Y. Long-term fatty liver-induced insulin resistance in orotic acid-induced nonalcoholic fatty liver rats. Biosci Biotechnol Biochem. 2016;80(4):735-43.

[12] Ann-Louise Gittleman. The Cinderella mineral that could defeat Alzheimer’s. Juni 2020.

[13] Moore GJ, et al. Lithium-induced increase in human brain grey matter. Lancet 2000; 356: 1,241-1,242.

[14] Sun YR, Herrmann N, Scott CJM, Black SE, Khan MM, Lanctôt KL. Global grey matter volume in adult bipolar patients with and without lithium treatment: A meta-analysis. J Affect Disord. 2018 Jan 1;225:599-606.

[15] Loria K. Psychiatrist: Maybe, Just Maybe, Everyone Should Take Lithium.

https://www.businessinsider.com/is-lithium-good-for-you-2014-12?r=US&IR=T

[16] Shao L, Cui J, Young LT, Wang JF. The effect of mood stabilizer lithium on expression and activity of glutathione s-transferase isoenzymes. Neuroscience. 2008 Jan 24;151(2):518-24.

[17] Greenblatt J. Low Dose Lithium For The Treatment Of Mood, Behavioral, And Cognitive Disorders. Föredrag 2016. https://www.greatplainslaboratory.com/webinars/2016/4/13/low-dose-lithium-for-the-treatment-of-mood-behavioral-and-cognitive-disorders

[18] Greenblatt J. Lithium: The mineral as medicine. Blogginlägg 2020-07-12. https://www.lowdoselithium.com/blog/2020/7/12/a-nobel-winning-technology-reaffirms-a-noble-nutritional

[19] Statens geologiska institut. ”Litium.” 2020-10-06. https://sgu.se/mineralnaring/kritiska-ravaror/litium/

[20] Shorter E. The history of lithium therapy. Bipolar Disord. 2009 Jun;11 Suppl 2(Suppl 2):4-9.

Dopamin - drivkraft, livslust och meningsfullhet

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Så mäter du intolerans mot födoämnen

1. Muraro A, Halken S, Arshad SH, et al. EAACI food allergy and anaphylaxis guidelines. Primary prevention of food allergy. Allergy 2014;69:590-601.

2. Muraro A, Werfel T, Hoffmann-Sommergruber K, et al. EAACI food allergy and anaphylaxis guidelines: diagnosis and management of food allergy. Allergy 2014;69:1008-25.

3. Carr S, Chan E, Lavine E, Moote W. CSACI Position statement on the testing of food-specific IgG. Allergy Asthma Clin Immunol 2012;8:12.

4. Johansson SG, Dannaeus A, Lilja G. The relevance of anti-food antibodies for the diagnosis of food allergy. Ann Allergy 1984;53(6 Pt 2):665-72.

5. Bernstein IL, Li JT, Bernstein DI, et al. Allergy diagnostic testing: an updated practice parameter. Ann Allergy Asthma Immunol 2008;100(3 Suppl 3):S1-148.

6. Carr S, Chan E, Lavine E, Moote W. CSACI Position statement on the testing of food-specific IgG. Allergy Asthma Clin Immunol 2012;8:12.

7. Bock SA. AAAAI support of the EAACI Position Paper on IgG4. J Allergy Clin Immunol 2010;125:1410.

8. Ruiter B, Knol EF, van Neerven RJ, Garssen J, Bruijnzeel-Koomen CA, Knulst AC, van Hoffen E. Maintenance of tolerance to cow's milk in atopic individuals is characterized by high levels of specific immunoglobulin G4. Clin Exp Allergy. 2007 Jul;37(7):1103-10.

9. Jones SM, Pons L, Roberts JL, et al. Clinical efficacy and immune regulation with peanut oral immunotherapy. J Allergy Clin Immunol 2009;124:292–300

10. Shakoor Z, AlFaifi A, AlAmro B, AlTawil LN, AlOhaly RY. Prevalence of IgG-mediated food intolerance among patients with allergic symptoms. Ann Saudi Med. 2016 Nov-Dec;36(6):386-390.

11. Karakula-Juchnowicz H, Gałęcka M, Rog J, et al. The Food-Specific Serum IgG Reactivity in Major Depressive Disorder Patients, Irritable Bowel Syndrome Patients and Healthy Controls. Nutrients. 2018;10(5):548. Published 2018 Apr 28.

12. Wang HY, Li Y, Li JJ, et al. Serological investigation of IgG and IgE antibodies against food antigens in patients with inflammatory bowel disease. World J Clin Cases. 2019;7(16):2189-2203.

13. Fedor I, Zold E, Barta Z. Food-specific IgG Antibodies in Crohn's Disease: What Came First, the Chicken or the Egg? Intern Med. 2019 Jul 15;58(14):2123.

14. Jian L, Anqi H, Gang L, Litian W, Yanyan X, Mengdi W, Tong L. Food Exclusion Based on IgG Antibodies Alleviates Symptoms in Ulcerative Colitis: A Prospective Study. Inflamm Bowel Dis. 2018 Aug 16;24(9):1918-1925.

15. Mitchell N, Hewitt CE, Jayakody S, Islam M, Adamson J, Watt I, Torgerson DJ. Randomised controlled trial of food elimination diet based on IgG antibodies for the prevention of migraine like headaches. Nutr J. 2011 Aug 11;10:85.

16. Aucoin M, Bhardwaj S. Major Depressive Disorder and Food Hypersensitivity: A Case Report. Neuropsychobiology. 2019;78(4):249-255.

17. Geiselman JF. The Clinical Use of IgG Food Sensitivity Testing with Migraine Headache Patients: a Literature Review. Curr Pain Headache Rep. 2019 Aug 27;23(11):79.

18. Lin S, Yang X, Xing Y, Wang X, Li Y. The Clinical Application Value of Multiple Combination Food Intolerance Testing. Iran J Public Health. 2019 Jun;48(6):1068-1073.

19. Veloso-Teles R, Cerejeira R, Rodrigues D, Roque-Farinha R, von Buchwald C. Food-Specific IgE and IgG Antibodies in Patients With Chronic Rhinosinusitis With Nasal Polyps: A Case-Control Study. Ear Nose Throat J. 2021 Mar;100(3):177-184.

20. Kaličanin D, Brčić L, Barić A, Zlodre S, Barbalić M, Torlak Lovrić V, Punda A, Boraska Perica V. Evaluation of Correlations Between Food-Specific Antibodies and Clinical Aspects of Hashimoto's Thyroiditis. J Am Coll Nutr. 2019 Mar-Apr;38(3):259-266.

Nr 6, 2020: Cancer

Så mäter du din kondition

Laukkanen JA, Kurl S, Salonen R, Rauramaa R, Salonen JT. The predictive value of cardiorespiratory fitness for cardiovascular events in men with various risk profiles: a prospective population-based cohort study.Eur Heart J. 2004; 25:1428–1437.
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Hur går det till när C-vitamin dödar cancerceller?

[1] Lim JY, Kim D, Kim BR, Jun JS, Yeom JS, Park JS, Seo JH, Park CH, Woo HO, Youn HS, Baik SC, Lee WK, Cho MJ, Rhee KH. Vitamin C induces apoptosis in AGS cells via production of ROS of mitochondria. Oncol Lett. 2016 Nov;12(5):4270-4276.

[2] Doskey CM, Buranasudja V, Wagner BA, Wilkes JG, Du J, Cullen JJ, Buettner GR. Tumor cells have decreased ability to metabolize H2O2: Implications for pharmacological ascorbate in cancer therapy. Redox Biol. 2016 Dec;10:274-284.

[3] Padayatty SJ, Sun AY, Chen Q, Espey MG, Drisko J, Levine M. Vitamin C: intravenous use by complementary and alternative medicine practitioners and adverse effects. PLoS One. 2010 Jul 7;5(7):e11414.

[4] Cameron E, Pauling L. Supplemental ascorbate in the supportive treatment of cancer: Prolongation of survival times in terminal human cancer. Proc Natl Acad Sci U S A. 1976 Oct;73(10):3685-9.

[5] Cameron E, Pauling L. Supplemental ascorbate in the supportive treatment of cancer: reevaluation of prolongation of survival times in terminal human cancer. Proc Natl Acad Sci U S A. 1978 Sep;75(9):4538-42.

[6] Chen P, Yu J, Chalmers B, Drisko J, Yang J, Li B, Chen Q. Pharmacological ascorbate induces cytotoxicity in prostate cancer cells through ATP depletion and induction of autophagy. Anticancer Drugs. 2012 Apr;23(4):437-44.

[7] Yun J, Mullarky E, Lu C, Bosch KN, Kavalier A, Rivera K, Roper J, Chio II, Giannopoulou EG, Rago C, Muley A, Asara JM, Paik J, Elemento O, Chen Z, Pappin DJ, Dow LE, Papadopoulos N, Gross SS, Cantley LC. Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH. Science. 2015 Dec 11;350(6266):1391-6.

[8] Padayatty SJ, Riordan HD, Hewitt SM, Katz A, Hoffer LJ, Levine M. Intravenously administered vitamin C as cancer therapy: three cases. CMAJ. 2006 Mar 28;174(7):937-42.

[9] Taxman ET, Conlon ED, Speers A, Dismuke KL, Heyman TS, Taxman TL. Chemotherapy and Functional Medicine in a Patient With Metastatic Breast Cancer: A Case Report. Integr Med (Encinitas). 2016 Mar;15(1):27-32.

[10] Mikirova N, Hunnunghake R, Scimeca RC, Chinshaw C, Ali F, Brannon C, Riordan N. High-Dose Intravenous Vitamin C Treatment of a Child with Neurofibromatosis Type 1 and Optic Pathway Glioma: A Case Report. Am J Case Rep. 2016 Oct 24;17:774-781.

[11] Carr AC, Cook J. Intravenous Vitamin C for Cancer Therapy - Identifying the Current Gaps in Our Knowledge. Front Physiol. 2018 Aug 23;9:1182.

[12] Thompson D. Intravenous Vitamin C May Boost Chemo's Cancer-Fighting Power. HealthDay, 2014-02-05.

[13] Chen Q, Espey MG, Krishna MC, Mitchell JB, Corpe CP, Buettner GR, Shacter E, Levine M. Pharmacologic ascorbic acid concentrations selectively kill cancer cells: action as a pro-drug to deliver hydrogen peroxide to tissues. Proc Natl Acad Sci U S A. 2005 Sep 20;102(38):13604-9.

[14] Lorenzato A, Magri A, Matafora V. Vitamin C Restricts the Emergence of Acquired Resistance to EGFR-Targeted Therapies in Colorectal Cancer. Cancers (Basel). 2020 Mar 14;12(3):685.

[15] Schoenfeld JD, Sibenaller ZA, Mapuskar KA, Wagner BA, Cramer-Morales KL, et al. O2⋅- and H2O2-Mediated Disruption of Fe Metabolism Causes the Differential Susceptibility of NSCLC and GBM Cancer Cells to Pharmacological Ascorbate. Cancer Cell. 2017 Apr 10;31(4):487-500.e8.

[16] Magri A, Germano G, Lorenzato A, Lamba S, Chilà R, et al. High-dose vitamin C enhances cancer immunotherapy. Sci Transl Med. 2020 Feb 26;12(532):eaay8707.

[17] Di Tano M, Raucci F, Vernieri C, Caffa I, Buono R et al. Synergistic effect of fasting-mimicking diet and vitamin C against KRAS mutated cancers. Nat Commun. 2020 May 11;11(1):2332.

[18] Vårdguiden. ”Vad är G6PD?” https://www.1177.se/Stockholm/fragor--svar/nationellt/sjukdomar--besvar/vad-ar-g6pd/ Hämtad 20-11-18.

Kan antioxidanter öka risken för cancer?

[1] Le Gal K, Ibrahim MX, Wiel C, Sayin VI, Akula MK, Karlsson C, Dalin MG, Akyürek LM, Lindahl P, Nilsson J, Bergo MO. Antioxidants can increase melanoma metastasis in mice. Sci Transl Med. 2015 Oct 7;7(308):308re8.

[2] Sayin VI, Ibrahim MX, Larsson E, Nilsson JA, Lindahl P, Bergo MO. Antioxidants accelerate lung cancer progression in mice. Sci Transl Med. 2014 Jan 29;6(221):221ra15.

[3] Sayin VI, Ibrahim MX, Larsson E, Nilsson JA, Lindahl P, Bergo MO. Antioxidants accelerate lung cancer progression in mice. Sci Transl Med. 2014 Jan 29;6(221):221ra15.

Mutationsteorins utmanare: ”Cancer kan inte leva utan glutamin och glukos”

[i] İyikesici MS, Slocum AK, Slocum A, Berkarda FB, Kalamian M, Seyfried TN. Efficacy of Metabolically Supported Chemotherapy Combined with Ketogenic Diet, Hyperthermia, and Hyperbaric Oxygen Therapy for Stage IV Triple-Negative Breast Cancer. Cureus. 2017 Jul 7;9(7):e1445.

[ii] https://www.facebook.com/pablosbrainjourney/

[iii] Meidenbauer JJ, Mukherjee P, Seyfried TN. The glucose ketone index calculator: a simple tool to monitor therapeutic efficacy for metabolic management of brain cancer. Nutr Metab (Lond). 2015 Mar 11;12:12.

[iv] Mukherjee P, Augur ZM, Li M, Hill C, Greenwood B, Domin MA, Kondakci G, Narain NR, Kiebish MA, Bronson RT, Arismendi-Morillo G, Chinopoulos C, Seyfried TN. Therapeutic benefit of combining calorie-restricted ketogenic diet and glutamine targeting in late-stage experimental glioblastoma. Commun Biol. 2019 May 29;2:200.

[v] Augur ZM, Doyle CM, Li M, Mukherjee P, Seyfried TN. Nontoxic Targeting of Energy Metabolism in Preclinical VM-M3 Experimental Glioblastoma. Front Nutr. 2018 Oct 5;5:91.

[vi] Mukherjee P, Augur ZM, Li M, Hill C, Greenwood B, Domin MA, Kondakci G, Narain NR, Kiebish MA, Bronson RT, Arismendi-Morillo G, Chinopoulos C, Seyfried TN. Therapeutic benefit of combining calorie-restricted ketogenic diet and glutamine targeting in late-stage experimental glioblastoma. Commun Biol. 2019 May 29;2:200.

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[viii] Poff AM, Ari C, Seyfried TN, D'Agostino DP. The ketogenic diet and hyperbaric oxygen therapy prolong survival in mice with systemic metastatic cancer. PLoS One. 2013 Jun 5;8(6):e65522.

[ix] İyikesici MS. Feasibility study of metabolically supported chemotherapy with weekly carboplatin/paclitaxel combined with ketogenic diet, hyperthermia and hyperbaric oxygen therapy in metastatic non-small cell lung cancer. Int J Hyperthermia. 2019;36(1):446-455.

[x] Pawelek JM. Fusion of bone marrow-derived cells with cancer cells: metastasis as a secondary disease in cancer. Chin J Cancer. 2014 Mar;33(3):133-9. doi: 10.5732/cjc.013.10243. PMID: 24589183; PMCID: PMC3966146.

[xi] Lazova R, Camp RL, Klump V, Siddiqui SF, Amaravadi RK, Pawelek JM. Punctate LC3B expression is a common feature of solid tumors and associated with proliferation, metastasis, and poor outcome. Clin Cancer Res. 2012 Jan 15;18(2):370-9.

[xii] Stratton MR, Campbell PJ, Futreal PA. The cancer genome. Nature. 2009 Apr 9;458(7239):719-24.

[xiii] Soto AM, Sonnenschein C. The somatic mutation theory of cancer: growing problems with the paradigm? Bioessays. 2004 Oct;26(10):1097-107.

[xiv] Aguilera O, Muñoz-Sagastibelza M, Torrejón B, Borrero-Palacios A, Del Puerto-Nevado L, Martínez-Useros J, Rodriguez-Remirez M, Zazo S, García E, Fraga M, Rojo F, García-Foncillas J. Vitamin C uncouples the Warburg metabolic switch in KRAS mutant colon cancer. Oncotarget. 2016 Jul 26;7(30):47954-47965.

Cancer och immunterapi

1. Douglas Hanahan, Robert A. Weinberg. Hallmarks of cancer: the next generation. Cell. 2011;144(5):646-74.

2. Maria V. Liberti, Jason W. Locasale. The Warburg Effect: How Does it Benefit Cancer Cells? Trends Biochem Sci. 2016;41(3):211-218.

3.Dominique C. Hinshaw, Lalita A. Shevde. The Tumor Microenvironment Innately Modulates Cancer Progression.

4. Grens K. Cancer Immunotherapy Trial Suspended After Deaths. The Scientist, 2016-07-08.

5. Söderlund Leifler K.Immunsystemet får hjälp att bekämpa cancer. Forskning & framsteg. 2014-06-08

6. John Hopkins Medicine. Side effects of immunotherapy: what to look for and when? Blogginlägg 2016-06-23.

7. John Hopkins Medicine. New Cancer Immunotherapy Drugs Linked To Arthritis in Some Patients. Pressmeddelande 2016-06-23.

8.https://www.pnas.org/content/early/2020/11/20/2015343117

9. Wang J, Yang HR, Wang DJ, Wang XX. Association between the gut microbiota and patient responses to cancer immune checkpoint inhibitors. Oncol Lett. 2020 Dec;20(6):342.

10. Cancerfonden. Kroppens eget försvar väcker hopp om bot. Blogginlägg 2014-05-28.

11. Wang J, Yang HR, Wang DJ, Wang XX. Association between the gut microbiota and patient responses to cancer immune checkpoint inhibitors. Oncol Lett. 2020 Dec;20(6):342.

12. Hawrelak JA, Myers SP. The causes of intestinal dysbiosis: a review. Altern Med Rev. 2004 Jun;9(2):180-97. PMID: 15253677.

13. Bastyr University. Probiotics and the Immune System. Blogginlägg 2010-11-08.

14. Kitamura M.How Gut Bacteria Are Shaking Up Cancer Research. Bloomberg 2016-03-14

15. UChicago News. Gut bacteria can dramatically amplify cancer immunotherapy. Pressmeddelande 2015-11-06.

16. Vétizou M, Pitt JM, Daillère R, et al. Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota. Science. 2015 Nov 27;350(6264):1079-84.

17. Ramin Rezaee, Amir Abbas Momtazi, Alireza Monemi, Amirhossein Sahebkar. Curcumin: A potentially powerful tool to reverse cisplatin-induced toxicity. Pharmacol Res. 2017;117:218-227.

18. Dona Sinha, Nivedita Sarkar, Jaydip Biswas, Anupam Bishayee. Resveratrol for breast cancer prevention and therapy: Preclinical evidence and molecular mechanisms. Semin Cancer Biol. 2016;40-41:209-232.

19. Lindsay G. Carter, John A. D’Orazio, Kevin J. Pearson. Resveratrol and cancer: focus on in vivo evidence. Endocr Relat Cancer. 2014;21(3):R209-R225.

Lästips:

Cancer: The Journey from Diagnosis to Empowerment, av Anderson, Paul.

A. Radical Remission: Surviving Cancer Against All Odds, av Turner, Kelly
Outside the Box Cancer Therapies: Alternative Therapies That Treat and Prevent Cancer, av Stengler, Mark, Anderson, Paul.
The Metabolic Approach to Cancer: Integrating Deep Nutrition, the Ketogenic Diet, and Nontoxic Bio-Individualized Therapies, av Winters, Nasha, Higgins Kelley, Jess, Turner, Jess,
Vital Strategies in Cancer, av Roach, Jim.

Tränar du? Du kan ändå röra dig farligt lite

Folkhälsomyndigheten
Saint-Maurice PF, Troiano RP, Bassett DR Jr, Graubard BI, Carlson SA, Shiroma EJ, Fulton JE, Matthews CE. Association of Daily Step Count and Step Intensity With Mortality Among US Adults.JAMA. 2020 Mar 24;323(12):1151-1160.
Physiology of Sport and Exercise Sixth Edition W. Larry Kenney et al
Rundqvist H, Veliça P, Barbieri L, Gameiro PA, Bargiela D, Gojkovic M, Mijwel S, Reitzner SM, Wulliman D, Ahlstedt E, Ule J, Östman A, Johnson RS. Cytotoxic T-cells mediate exercise-induced reductions in tumor growth. Elife. 2020 Oct 23;9:e59996.

Metabol ohälsa kan förvärra covid-19

de Menezes, Ehrika Vanessa Almeida, et al. "Influence of Paleolithic diet on anthropometric markers in chronic diseases: systematic review and meta-analysis." Nutrition journal 18.1 (2019): 41.

Yancy, William S., et al. "A low-carbohydrate, ketogenic diet to treat type 2 diabetes." Nutrition & metabolism 2.1 (2005): 34.
Masharani, Umesh, et al. "Metabolic and physiologic effects from consuming a hunter-gatherer (Paleolithic)-type diet in type 2 diabetes." European journal of clinical nutrition 69.8 (2015): 944-948.
Jönsson, Tommy, et al. "Beneficial effects of a Paleolithic diet on cardiovascular risk factors in type 2 diabetes: a randomized cross-over pilot study." Cardiovascular diabetology 8.1 (2009): 35.
Fontes-Villalba, Maelán, et al. "Palaeolithic diet decreases fasting plasma leptin concentrations more than a diabetes diet in patients with type 2 diabetes: a randomised cross-over trial." Cardiovascular Diabetology 15.1 (2016): 80.
Frassetto, Lynda A., et al. "Established dietary estimates of net acid production do not predict measured net acid excretion in patients with Type 2 diabetes on Paleolithic–Hunter–Gatherer-type diets." European journal of clinical nutrition 67.9 (2013): 899-903.
Jönsson, Tommy, et al. "Subjective satiety and other experiences of a Paleolithic diet compared to a diabetes diet in patients with type 2 diabetes." Nutrition journal 12.1 (2013): 105.
Al-Saady, N. M., C. M. Blackmore, and E. D. Bennett. "High fat, low carbohydrate, enteral feeding lowers PaCO 2 and reduces the period of ventilation in artificially ventilated patients." Intensive care medicine 15.5 (1989): 290-295.
Lakka, Timo A., and David E. Laaksonen. "Physical activity in prevention and treatment of the metabolic syndrome." Applied physiology, nutrition, and metabolism 32.1 (2007): 76-88.

Kallbad som medicin

Huttunen, Pirkko, Leena Kokko, and Virpi Ylijukuri. "Winter swimming improves general well-being." International Journal of Circumpolar Health 63.2 (2004): 140-144.
Hirvonen, Jorma, et al. "Plasma catecholamines, serotonin and their metabolites and beta-endorphin of winter swimmers during one winter. Possible correlations to psychological traits." International journal of circumpolar health 61.4 (2002): 363-372.
Lindeman, Sari, Jorma Hirvonen, and Matti Joukamaa. "Neurotic psychopathology and alexithymia among winter swimmers and controls-a prospective study." International journal of circumpolar health 61.2 (2002): 123-130.
Peake, Jonathan M., et al. "The effects of cold water immersion and active recovery on inflammation and cell stress responses in human skeletal muscle after resistance exercise." The Journal of physiology 595.3 (2017): 695-711.
Siems, W. G., et al. "Improved antioxidative protection in winter swimmers." Qjm 92.4 (1999):
Mooventhan, A., and L. Nivethitha. "Scientific evidence-based effects of hydrotherapy on various systems of the body." North American journal of medical sciences 6.5 (2014): 199.

Nr 5, 2020: Karnivorkost

Regenerativt jordbruk för hållbar hälsa och bättre miljö

Lancaster University. Global study reveals time running out for many soils - but conservation measures can help. Pressmeddelande 2020-09-14.
Willett W, Rockström J, Loken B, et al. Food in the Anthropocene: the EAT-Lancet Commission on healthy diets from sustainable food systems [published correction appears in Lancet. 2019 Feb 9;393(10171):530] [published correction appears in Lancet. 2019 Jun 29;393(10191):2590] [published correction appears in Lancet. 2020 Feb 1;395(10221):338]. Lancet. 2019;393(10170):447-492.
Cornell S, Crona B, Jonell M m.fl. Ställ om snabbt till nyttigare och mer klimatsmart mat. Debattartikel, DN 2017-01-18.
Edman S, Gardfjell M, Granstedt A m.fl. En global diet skulle leda till katastrof. Replik på debattartikel, DN 2017-01-18.
LaCanne CE, Lundgren JG. Regenerative agriculture: merging farming and natural resource conservation profitably. PeerJ. 2018 Feb 26;6:e4428.

Djuruppfödning – ett mynt med två sidor

https://www.swissinfo.ch/eng/factory-farming_swiss-government-gives-animal-welfare-a-boost/45525498
samt konversation med Schweiz ambassad som bekräftat påståendena i texten.
Danska kycklingproducenter: Tidningen Syre
https://tidningensyre.se/2020/20-april/dansk-jatte-fasar-ut-turbokycklingar/
Pandemi och kött, professor Björn Olsen som skrivit boken Pandemi:
https://www.aftonbladet.se/nyheter/a/P9A1db/professorn-inga-pandemier-om-alla-hade-varit-vegetarianer

Karnivorkostens historia

Harrison, Adrian, and Else Marie Bartels. "A Comparison of Ancient Greek and Roman Sports Diets with Modern Day Practices." Sports Nutrition and Therapy 1.1 (2016).
Lieb, Clarence W. "The effects of an exclusive, long-continued meat diet: Based on the history, experiences and clinical survey of Vilhjalmur Stefansson, Arctic explorer." Journal of the American Medical Association 87.1 (1926): 25-26.
Cordain, Loren, et al. "Plant-animal subsistence ratios and macronutrient energy estimations in worldwide hunter-gatherer diets." The American journal of clinical nutrition 71.3 (2000): 682-692.

Vanliga besvär vid omställning till karnivorkost

Harvey, Cliff JdC, et al. "Effects of differing levels of carbohydrate restriction on the achievement of nutritional ketosis, mood, and symptoms of carbohydrate withdrawal in healthy adults: A randomized clinical trial." Nutrition: X (2019): 100005.
Hernandez, Teri L., et al. "Lack of suppression of circulating free fatty acids and hypercholesterolemia during weight loss on a high-fat, low-carbohydrate diet." The American journal of clinical nutrition 91.3 (2010): 578-585.
Hernandez, Teri L., et al. "Lack of suppression of circulating free fatty acids and hypercholesterolemia during weight loss on a high-fat, low-carbohydrate diet." The American journal of clinical nutrition 91.3 (2010): 578-585.
Tiwari, Swasti, Shahla Riazi, and Carolyn A. Ecelbarger. "Insulin's impact on renal sodium transport and blood pressure in health, obesity, and diabetes." American Journal of Physiology-Renal Physiology 293.4 (2007): F974-F984.
Kelley, David E., and Bret H. Goodpaster. "Skeletal muscle triglyceride. An aspect of regional adiposity and insulin resistance." Clinical Diabetology 2.4 (2001): 255-266.

Därför kan uteslutningsdieter vara symtomlindrande

Maria J.E. Visser, Douglas B. Kell, Etheresia Pretorious. Bacterial Dysbiosis and Translocation in Psoriasis Vulgaris. Front Cell Infect Microbiol. 2019; 9:7.
Mariusz Sikora, Albert Stec, Magdalena Chrabaszcz, Aleksandra Knot, Anna Waskiel-Burnat, Adriana Rakowska, Malgorzata Olszewska, Lidia Rudnicka. Gut Microbiome in Psoriasis: An Updated Review. Pathogens. 2020;9(6):463.
Jose U Scher, Andrew Sczesnak, Randy L Longman, Nicola Segata, Carles Ubeda, Craig Bielski, Tim Rostron, Vincenzo Cerundolo, Eric G Palmer, Steven B Abramson, Curtis Huttenchower, Dan R Littman. Expansion of intenstinal Prevotella copri correlates with enhanced susceptibility to arthritis. eLife. 2013;2:e01202.
A Ebringer. The relationship between Klebsiella infection and akylosing spondylitis. Baillieres Clin Rheumatol. 1989;3(2):321-38.
Yvonne J. Huang, Homer A. Boushey. The Microbiome in Asthma. J Allergy Clin Immunol. 2015;135(1):25-30.
Taha Rashid, Clyde Wilson, Alan Ebringer. The link between ankylosing spondylitis, Chron’s disease, Klebsiella, and starch consumption. Clin Dev Immunol. 2013:872632.

“Inälvsmat är superfood” - intervju med Paul Saladino

Så mäter du bäst ditt kroppsfett

Rocha R, Cotrim HP, Carvalho FM, Siqueira AC, Braga H, Freitas LA. Body mass index and waist circumference in non-alcoholic fatty liver disease. J Hum Nutr Diet. 2005;18:365–370.
Eguchi Y, Eguchi T, Mizuta T, Ide Y, Yasutake T, Iwakiri R, Hisatomi A, Ozaki I, Yamamoto K, Kitajima Y et al. Visceral fat accumulation and insulin resistance are important factors in nonalcoholic fatty liver disease. J Gastroenterol. 2006;41:462–469.
van der Poorten D, Milner KL, Hui J, Hodge A, Trenell MI, Kench JG, London R, Peduto T, Chisholm DJ, George J. Visceral fat: a key mediator of steatohepatitis in metabolic liver disease. Hepatology. 2008;48:449–457.
Almeida NS, Rocha R, Cotrim HP, Daltro C. Anthropometric indicators of visceral adiposity as predictors of non-alcoholic fatty liver disease: A review. World J Hepatol 2018; 10(10): 695-701.

Nr 4, 2020: Klimakteriet

Glutation stoppade svåra andningsbesvär hos två coronasmittade patienter

1) Klein, Melissa. ”New York mom with coronavirus saved by medical-student son’s quick thinking.” New York Post, 2020-05-09.

2) Horowitz RI, Freeman PR, Bruzzese J. Efficacy of glutathione therapy in relieving dyspnea associated with COVID-19 pneumonia: A report of 2 cases. Respir Med Case Rep. 2020 Apr 21:101063.

3) Polonikov A. Endogenous Deficiency of Glutathione as the Most Likely Cause of Serious Manifestations and Death in COVID-19 Patients. ACS Infect Dis. 2020 May 28;acsinfecdis.0c00288.

4) Hemilä H, Louhiala P. Vitamin C for preventing and treating pneumonia (Review). The Cochrane Library 2013, Issue 8.

5) Lenton KJ, Sané AT, Therriault H, et al. Vitamin C Augments Lymphocyte Glutathione in Subjects With Ascorbate Deficiency. Am J Clin Nutr. 2003 Jan;77(1):189-95.

6) Waly MI, Al-Attabi Z, Guizani N. Low Nourishment of Vitamin C Induces Glutathione Depletion and Oxidative Stress in Healthy Young Adults. Prev Nutr Food Sci. 2015 Sep; 20(3): 198–203.

7) Montecinos V, Guzmán P, Barra V et al. Vitamin C Is an Essential Antioxidant That Enhances Survival of Oxidatively Stressed Human Vascular Endothelial Cells in the Presence of a Vast Molar Excess of Glutathione. The Journal of Biological Chemistry 282, 15506-15515.

Klimakteriebesvär – ett modernt problem?

Mellby MK, Lock M, Kaufert P. Culture and symptom reporting at menopause. Human Reprod Update. 2005;11(5):495-512.
Hunter M, Rendall M. Bio-psycho-socio-cultural perspectives on menopause. Best Pract Res Clin Obstet Gynaecol. 2007;21(2):261-74.
Henryk Dancygier. Hepatic Biotransformation. Clinical Hepatology. 127-130.
Schutz K, Carle R, Schieber A. Taraxacum—a review on its phytochemical and pharmacological profile. J Ethnopharmacol. 2006;107(3):313-23.
Hassan Malekinejad, Aysa Rezabakhsh. Hormones in Dairy Foods and Their Impact on Public Health – A Narrative Review Article. Iran J Public Health. 2015;44(6):742-758.
A.C. Gore, V.A. Chapell, S.E. Fenton, J.A. Flaws, A. Nadal, G.S. Prins, J. Toppari, R.T. Zoeller. EDC-2: The Endocrine Society’s Second Scientific Statement on Endocrine-Disrupting Chemicals. Endocr Rev. 2015;36(6):E1-E150.
Mangala Bhaskar Murthy, Bhaskar K. Murthy. Thyroid disruptors and their possible clinical implications. Indian J Pharmacol. 2012;44(4):542-543.
https://www.ewg.org/consumer-guides
Dobrek L. The outline of stress pathophysiology and pharmacodynamic action of plant-based eustressors – adaptogens. Pol Merkur Lekalski. 2019;46(273):103-108.
Chandrasekhar K, Kapoor J, Anishetty S. A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults. Indian J Psychol Med. 2012;34(3):255-62.
Hoang Viet Bach, Jeongseon Kim, Seung-Kwon Myung, Young Ae Cho. Efficacy of Ginseng Supplements on Fatigue and Physical Performance: a Meta-analysis. J Korean Med Sci. 2016;31(12):1879-1886.
Gustavo F. Gonzales. Ethnobiology and Ethnopharmacology of Lepidium meyenii (Maca), a Plant from the Peruvian Highlands. Evid Based Complement Alternativ Med. 2012; 2012: 193496.

Hormonersättning kan förebygga sjukdomar och förlänga livet

Bitner D, Brightman R, Graham S, et al. E2/P4 capsules effectively treat vasomotor symptoms irrespective of age and BMI. Poster presented at: North American Menopause Society Annual Meeting; September 25-28, 2019; Chicago, IL.https://www.menopause.org/docs/default-source/agm/poster-session-abstracts.pdf
Baber RJ, Panay N, Fenton A, the IMS Writing Group. 2016 IMS Recommendations on women’s midlife health and menopause hormone therapy, Climacteric, 19:2, 109-150 https://www.imsociety.org/manage/images/pdf/4429e3dd302aac259ad68c3be7f60599.pdf

Viktökning i klimakteriet ”Hjälp, vad är det som händer?”

1. Lizcano F, Guzmán G. Estrogen Deficiency and the Origin of Obesity during Menopause. Biomed Res Int. 2014;2014:757461. doi: 10.1155/2014/757461. Epub 2014 Mar 6.

2. Shimokata H1, Kuzuya F. Aging, basal metabolic rate, and nutrition. Nihon Ronen Igakkai Zasshi. 1993 Jul;30(7):572-6. https://www.ncbi.nlm.nih.gov/pubmed/8361073

Omdebatterat piller fyller 60 år - vad alla kvinnor borde veta om p-piller

Mørch LS, Skovlund CW, Hannaford PC, Iversen L, Fielding S, Lidegaard Ø. Contemporary Hormonal Contraception and the Risk of Breast Cancer. N Engl J Med. 2017;377(23):2228‐2239.
Skovlund CW, Mørch LS, Kessing LV, Lidegaard Ø. Association of Hormonal Contraception With Depression [published correction appears in JAMA Psychiatry. 2017 Jul 1;74(7):764]. JAMA Psychiatry. 2016;73(11):1154‐1162. (kommentar: Denna är omtalad och nämns bland annat här: https://www.health.harvard.edu/blog/can-hormonal-birth-control-trigger-depression-2016101710514)
Shufelt CL, Bairey Merz CN. Contraceptive hormone use and cardiovascular disease [published correction appears in J Am Coll Cardiol. 2009 Mar 10;53(10):904]. J Am Coll Cardiol. 2009;53(3):221‐231. doi:10.1016/j.jacc.2008.09.042
Zethraeus N, Dreber A, Ranehill E, et al. A first-choice combined oral contraceptive influences general well-being in healthy women: a double-blind, randomized, placebo-controlled trial. Fertil Steril. 2017;107(5):1238‐1245.
Geiger AM, Foxman B. Risk factors for vulvovaginal candidiasis: a case-control study among university students. Epidemiology. 1996;7(2):182‐187.
Guo Y, Qi Y, Yang X, et al. Association between Polycystic Ovary Syndrome and Gut Microbiota. PLoS One. 2016;11(4):e0153196. Published 2016 Apr 19.
Leonardi M, Hicks C, El-Assaad F, El-Omar E, Condous G. Endometriosis and the microbiome: a systematic review. BJOG. 2020;127(2):239‐249.

Haydeh Bolouri: ”Det går att förebygga och vända alzheimer”

1. Bolouri H., Hajimirsadeghi A. A Holistic Approach and Successful Treatment of Chronic Wound in Diabetes Mellitus by Platelet-Rich Plasma (PRP) Combined with Optimized Diet. Dermatology Case Reports, 2017,2:3.

2. Kivipelto M, Solomon A, Ahtiluoto S et al. The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER): Study Design and Progress. Alzheimers Dement. 2013 Nov;9(6):657-65

3. Kennedy M. Varannan blir sjuk av vanliga läkemedel. GöteborgsPosten, 2014-06-16.

Bredesen qDE, Amos EC, Canick J, Ackerley M, Raji C, Fiala M, Ahdidan J. Reversal of cognitive decline in Alzheimer's disease. Aging (Albany NY). 2016; 8:1250-1258.

Livsstilsbehandling mot tidig alzheimer

1) Bredesen DE, Amos EC, Canick J, Ackerley M, Raji C, Fiala M, Ahdidan J. Reversal of cognitive decline in Alzheimer’s disease. Aging 2016 Jun;8(6):1250-8.

2) Bredesen D.E., Sharlin K., Jenkins D. m.fl. Reversal of Cognitive Decline: 100 Patients. Alzheimers Dis Parkinsonism. 2019; 8(5).

Nr 3, 2020: Migrän

Hjälper intravenöst C-vitamin mot Coronaviruset? av Lina Åhlén, hälsoskribent

Chen N., Zhou M., Dong X. et.al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. The Lancet. 2020;395:10223. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30211-7/fulltext
Wald E.L., Sanchez-Pinto N., Smith C.M. et.al. Hydrocortisone-Ascorbic Acid-Thiamine Use Associated with Lower Mortality in Pediatric Septic Shock. ATS Journals. 2020;January
Fowler A.A., Truwit J.D., Duncan Hite R. et.al. Effect of Vitamin C Infusion on Organ Failure and Biomarkers of Inflammation and Vascular Injury in Patients With Sepsis and Severe Acute Respiratory Failure. JAMA. 2019:322;13
Fujii T., Luethi N., Young P.J. et.al. Effect of Vitamin C, Hydrocortisone, and Thiamine vs Hydrocortisone Alone on Time Alive and Free of Vasopressor Support Among Patients With Septic Shock. JAMA Networks. 2020;323:5
Peng Z. Vitamin C Infusion for the Treatment of Severe 2019-nCoV Infected Pneumonia. U.S. National Library of Medicine, Clinicaltrials.gov. 2020;Feb https://clinicaltrials.gov/ct2/show/NCT04264533
Roa F.J., Peña E., Gatica M. et.al. Therapeutic Use of Vitamin C in Cancer: Physiological Considerations. Frontiers in Pharmacology. 2020;11:211
Kim H., Jang M., Kim Y. et al. Red ginseng and vitamin C increase immune cell activity and decrease lung inflammation induced by influenza A virus/H1N1 infection. Journal of Parmacy and Pharmacology. 2016:68;3
Matthay M.A., Aldrich J.M., Gotts J.E. et. al. Treatment for severe acute respiratory distress syndrome from COVID-19. THE LANCET Respiratory Medicine. 2020;March.
Fowler A.A., Truwit J.D., Duncan Hite R. et.al. Effect of Vitamin C Infusion on Organ Failure and Biomarkers of Inflammation and Vascular Injury in Patients With Sepsis and Severe Acute Respiratory Failure. JAMA. 2019:322;13
Jonsson B.H. Bör inte död vara ett primärt utfallsmått i sepsisstudier? Läkartidningen. 2020;Mar https://lakartidningen.se/opinion/debatt/2020/03/bor-inte-dod-vara-ett-primart-utfallsmatt-i-sepsisstudier/
Mongelli L, Golding B. New York hospitals treating coronavirus patients with vitamin C. New York Post. 2020;March https://nypost.com/2020/03/24/new-york-hospitals-treating-coronavirus-patients-with-vitamin-c/
Erol A. High-dose intravenous vitamin C treatment for COVID-19. Researchgate. 2020;Feb https://osf.io/p7ex8/

Kan man stärka sitt immunförsvar? av Peter Martin, leg läkare, med dr

Migrän - här är symtomen av Markus Mattiasson, biomedicinare och hälsoskribent

Varför får man migrän? av Markus Mattiasson, biomedicinare och hälsoskribent

Metoderna som lindrar av Markus Mattiasson, biomedicinare och hälsoskribent

Ett funktionsmedicinskt perspektiv - Den individuella migräntröskeln av Markus Mattiasson, biomedicinare och hälsoskribent’

Nr 2, 2020: Mitokondrier

Mitokondrierna - kroppens energiverk av Lina Åhlén, hälsoskribent

Marcheggiani F., Cirilli I., Orando P. et.al. Modulation of Coenzyme Q10 content and oxidative status in human dermal fibroblasts using HMG-CoA reductase inhibitor over a broad range of concentrations. From mitohormesis to mitochondrial dysfunction and accelerated aging. Aging. May 2019:10:11(9). https://www.ncbi.nlm.nih.gov/pubmed/31076563
Hsu C-C, Tseng L-M., Lee H-C. Role of mitochondrial dysfunction in cancer progression. 2016. March
Chen L., Knowlton A.A. Mitochondria and heart failure: new insights into an energetic problem. Minerva Cardiology. 2010. Apr 58(2) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3786553/
Mortiboys H., Macdonald R., Payne T. Translational approaches to restoring mitochondrial function in Parkinson’s disease. 2018. Jan (582). https://febs.onlinelibrary.wiley.com/doi/pdf/10.1002/1873-3468.12920
Pei-I T., Chin-Hsien L., Chung-Han H., et.al. PINK1 Phosphorylates MIC60/Mitofilin to Control Structural Plasticity of Mitochondrial Crista Junctions. Molecular Cell. 2018 March 69(5). https://parkinsonsnewstoday.com/2018/02/27/defects-in-mitochondria-linked-to-parkinsons-stanford-study/
Perez Ortiz J.M., Swerdlow R.H. Mitochondrial dysfuncion in Alzheimer’s disease: Role in pathogenesis and novel therapeutic opportunities. British Journal of Pharmacology. 2019:176. https://bpspubs.onlinelibrary.wiley.com/doi/epdf/10.1111/bph.14585
Ames B., Liu J., Killilea D.W. Age-associated mitochondrial oxidative decay: Improvement of carnitine acetyltransferase substrate-binding affinity and activity in brain by feeding old rats acetyl-l- carnitine and/or R-α-lipoic acid. 2002. Feb 99(4). https://www.pnas.org/content/99/4/1876.short

Mitokondriefunktion - grundläggande för vår hälsa av Markus Mattiasson, biomedicinare och hälsoskribent

Metabolomik ger inblick i mitokondriens värld av Annie Pettersson, fil.mag. (biologi) från Uppsala universitet och fil.dr. (medicin) från Karolinska Institutet

Astarita G, Langridge J. J Nutrigenet Nutrigenomics. 2013;6(4-5):181-200. An emerging role for metabolomics in nutrition science.
Chen Q et al. Front Cell Neurosci. 2019 Apr 30;13:150. Urine Organic Acids as Potential Biomarkers for Autism-Spectrum Disorder in Chinese Children.
Depeint F et al. Chem Biol Interact. 2006 Oct 27;163(1-2):94-112. Mitochondrial function and toxicity: role of the B vitamin family on mitochondrial energy metabolism.
Filler K et al. BBA Clin. 2014 Jun 1;1:12-23. Association of Mitochondrial Dysfunction and Fatigue: A Review of the Literature.
Gallagher R et al. Genetics in Medicine volume 20, pages 683–691(2018) Laboratory analysis of organic acids, 2018 update: a technical standard of the American College of Medical Genetics and Genomics (ACMG)
Guillemin GJ et al. FEBS J. 2012 Apr;279(8):1356-65. Quinolinic acid, the inescapable neurotoxin.
Kałużna-Czaplińska et al. Nutrition Research. Volume 31, Issue 7, July 2011, Pages 497-502. B vitamin supplementation reduces excretion of urinary dicarboxylic acids in autistic children
Longo et al. Biochim Biophys Acta. 2016 Oct; 1863(10): 2422–2435. CARNITINE TRANSPORT AND FATTY ACID OXIDATION
McKillop et al. Diabetes Care. 2011 Dec; 34(12): 2624–2630.
Emerging Applications of Metabolomic and Genomic Profiling in Diabetic Clinical Medicine
Moskowitz A et al. J Intensive Care Med. 2016 Mar;31(3):187-92. The Association Between Admission Magnesium Concentrations and Lactic Acidosis in Critical Illness.
Nordholme et al. Läkartidningen. 2016;113:DR7E Tiaminbrist orsakade laktacidos hos patient med malnutrition - Många patienter i behov av behandling med tiamin missas sannolikt.
Noto A et al. J Matern Fetal Neonatal Med. 2014 Oct;27 Suppl 2:46-52. The urinary metabolomics profile of an Italian autistic children population and their unaffected siblings.
Orozco JS et al. Transl Psychiatry. 2019 Oct 3;9(1):243. Metabolomics analysis of children with autism, idiopathic-developmental delays, and Down syndrome.
Osiezagha, K et al. Innov Clin Neurosci. 2013 Apr; 10(4): 26–32. Thiamine Deficiency and Delirium
Pieczenik SR & Neustadt J. Exp Mol Pathol. 2007 Aug;83(1):84-92. Mitochondrial dysfunction and molecular pathways of disease.
Sun J et al. Per Med. 2013 Mar;10(2):149-161. Metabolomics as a tool for personalizing medicine: 2012 update.
Teagarden et al. Case Rep Crit Care. 2017;2017:5121032. Thiamine Deficiency Leading to Refractory Lactic Acidosis in a Pediatric Patient.
Tsoukalas D et al. Int J Mol Med. 2017 Jul;40(1):112-120. Application of metabolomics: Focus on the quantification of organic acids in healthy adults.

Deanna Minich - Vi måste ge mitokondrierna den näring de behöver av Nina Törmark, journalist

Fasta - ett kraftfullt verktyg för optimal hälsa av Annie Pettersson, fil.mag. (biologi) från Uppsala universitet och fil.dr. (medicin) från Karolinska Institutet

Dror, et al. Postprandial macrophage-derived IL-1β stimulates insulin and both synergistically promote glucose disposal and inflammation. Nature Immunology, January 2017
Seillet et al. Nat Immunol. 2020 Feb;21(2):168-177. The neuropeptide VIP confers anticipatory mucosal immunity by regulating ILC3 activity.
Anton et al. Obesity (Silver Spring). 2018 Feb;26(2):254-268. Flipping the Metabolic Switch: Understanding and Applying the Health Benefits of Fasting.
de Cabo & Mattson. N Engl J Med 2019;381:2541-51. Effects of Intermittent Fasting on Health, Aging, and Disease
Harvie & Howell. Potential benefits and harms of intermittent energy restriction and intermittent fasting amongst obese, overweight and normal weight subjects — a narrative review of human and animal evidence. Behav Sci (Basel) 2017; 7(1): E4.
Furmli et al. Therapeutic use of intermittent fasting for people with type 2 diabetes as an alternative to insulin. BMJ Case Rep 2018; 2018:bcr-2017-221854.
Sutton et al. Early time-restricted feeding improves insulin sensitivity, blood pressure, and oxidative stress even without weight loss in men with prediabetes. Cell Metab 2018; 27(6): 1212-1221.e3.
Nencioni et al. Fasting and cancer: molecular mechanisms and clinical application. Nat Rev Cancer 2018; 18: 707-19.
Choi et al. A diet mimicking fasting promotes regeneration and reduces autoimmunity and multiple sclerosis symptoms. Cell Rep 2016; 15: 2136-46.
Fitzgerald et al. Effect of intermittent vs. daily calorie restriction on changes in weight and patient-reported outcomes in people with multiple sclerosis. Mult Scler Relat Disord 2018; 23: 33-9.
Johnson et al. Alternate day calorie restriction improves clinical findings and reduces markers of oxidative stress and inflammation in overweight adults with moderate asthma. Free Radic Biol Med 2007; 42: 665-74.
Cignarella et al. Intermittent fasting confers protection in CNS autoimmunity by altering the gut microbiota. Cell Metab 2018; 27(6): 1222.e6-1235.e6.

Sött som socker men ändå inte av Pia Andrea, hälsoskribent

Nr 1, 2020: Oxalater

Tillsatserna som förvärrar stress Pia Andrea, hälsoskribent

Överkonsumtion av oxalater - en stundande hälsokris av Helene Sandström, vetenskapsjournalist

Testdata enligt The VP Foundation: www.thevpfoundation.org
Andrew Weil. ”How dangerous are oxalates?” Blogginlägg 2018-05-21. https://www.drweil.com/diet-nutrition/food-safety/how-dangerous-are-oxalates/. Läst 2019-10-24.
Michael Greger. ”Oxalates in Spinach and Kidney Stones: Should We Be Concerned?” Blogginlägg 2019-06-17. https://nutritionfacts.org/video/oxalates-in-spinach-and-kidney-stones-should-we-be-concerned/. Läst 2019-10-24.

Mer om oxalater: Norton, Sally K. (2018) ”Lost Seasonality and Overconsumption of Plants: Risking Oxalate Toxicity”, Journal of Evolution and Health: Vol. 2: Iss. 3, Article 4. https://doi.org/10.15310/2334-3591.1085

Oxalater som hälsoproblem - en funktionsmedicinsk betraktelse av Peter Martin, leg läkare, med dr

Kopplingen mellan oxalater och njursten av Mikaela Bjerring, näringsterapeut och hälsoskribent

Coe F. L., Evan A., Worcester E. Kidney stone disease. Journal of Clinical Investigation. 2005;115(10):2598–2608. doi: 10.1172/jci26662. https://www.ncbi.nlm.nih.gov/pubmed/16200192
Kidney Stone Disease: An Update on Current Concepts. Adv Urol. 2018; 2018: 3068365. Published online 2018 Feb 4. doi: 10.1155/2018/3068365. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5817324/
Dal-Moro F., Mancini M., Tavolini I. M., De Marco V., Bassi P. Cellular and molecular gateways to urolithiasis: a new insight. Urologia Internationalis. 2005;74:193–197. doi: 10.1159/000083547. https://www.ncbi.nlm.nih.gov/pubmed/15812202
Kishore D. V., Moosavi F., Varma D. R. K. Effect of ethanolic extract of Portulaca oleracea linn. on ethylene glycol and ammonium chloride induced urolithiasis. International Journal of Pharmacy and Pharmaceutical Sciences. 2013;5(2):134–140.
Kumar S. B. N., Kumar K. G., Srinivasa V., Bilal S. A review on urolithiasis. International Journal of Universal Pharmacy and Life Sciences. 2012;2(2):269–280.
Effects of citrate on the different phases of calcium oxalate crystallization. Scanning Microsc. 1993 Mar;7(1):381-9; discussion 389-90. https://www.ncbi.nlm.nih.gov/pubmed/8316807
Effect of Potassium Magnesium Citrate and Vitamin B-6 Prophylaxis for Recurrent and Multiple Calcium Oxalate and Phosphate Urolithiasis. Korean J Urol. 2014 Jun; 55(6): 411–416. Published online 2014 Jun 16. doi: 10.4111/kju.2014.55.6.411. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4064051/
Calcium intake and urinary stone disease. Transl Androl Urol. 2014 Sep; 3(3): 235–240. doi: 10.3978/j.issn.2223-4683.2014.06.05. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4708574/
Vitamin B6 intake and the risk of incident kidney stones. Urolithiasis. 2018 Jun;46(3):265-270. doi: 10.1007/s00240-017-0999-5. Epub 2017 Jul 3.https://www.ncbi.nlm.nih.gov/pubmed/28674784
Intake of vitamins B6 and C and the risk of kidney stones in women. J Am Soc Nephrol. 1999 Apr;10(4):840-5. https://www.ncbi.nlm.nih.gov/pubmed/10203369
5 steps for preventing kidney stones. Posted October 04, 2013, 12:30 pm , Updated July 18, 2019. https://www.health.harvard.edu/blog/5-steps-for-preventing-kidney-stones-201310046721
Taylor EN, Fung TT, Curhan GC. DASH-style diet associates with reduced risk for kidney stones. Journal of the American Society of Nephrology. 2009;20(10):2253–2259
https://ghr.nlm.nih.gov/condition/primary-hyperoxaluria
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3332067/
https://www.researchgate.net/publication/51048566_Physiological_roles_of_renal_anion_transporters_NaS1_and_Sat1

Lita på mig! Jag är läkare – säger Michael Mosley av Nina Törmark, journalist

Vi kommer ägna oss mer åt prevention av Nina Törmark, journalist

Impaired Sensitivity to Thyroid Hormones Is Associated With Diabetes and Metabolic Syndrome
http://care.diabetesjournals.org/content/early/2018/12/09/dc18-141

Ny studie visar: Bättre livskvalitet med funktionsmedicin av Helene Sandström, vetenskapsjournalist

The Institute for Functional Medicine. Two years in: What’s happening at Cleveland Clinic’s Center for Functional Medicine https://www.ifm.org/partnerships/cleveland-clinic-center-for-functional-medicine/ Hämtad 2019-11-07.
Cleveland Clinic. Functioning for Life. https://my.clevelandclinic.org/departments/functional-medicine/programs/functioning-for-life-appointments Hämtad 2019-11-07.

Nr 6, 2019: Svamp och parasiter

Ost som främjar hälsan av Pia Andrea, hälsoskribent

Candida och svampdysbios - erfarenheter från funktionsmedicinsk praktik av Peter Martin, leg. läkare, med. dr.

A Homei, M. Worboys. 2013. Fungal Disease in Britain and the United States 1850-2000: Mycoses and Modernity. E-PDF ISBN 9781137377029. DOI 10.1057/9781137377029.
Erdogan A & Rao SS. Small intestinal fungal overgrowth. Curr Gastroenterol Rep. 2015 Apr;17(4):16. doi: 10.1007/s11894-015-0436-2.
https://www.internetmedicin.se/page.aspx?id=615
Roshonda B Jones et al 2018. Inter-niche and inter-individual variation in gut microbial community assessment using stool, rectal swab, and mucosal samples. Scientific Reportsvolume 8, Article number: 4139
https://www.nature.com/articles/s41598-018-22408-4

Bättre effekt mot malaria med extrakt av hel malört av Helene Sandström, vetenskapsjournalist

Wellcome Trust Sanger Institute. Multidrug-resistant malaria spreading in Asia: Study reveals importance of genomic surveillance for malaria control strategies. ScienceDaily. ScienceDaily, 23 July 2019.
Miotto O, Sekihara M, Tachibana S-I et al. Emergence of artemisinin-resistant Plasmodium falciparum with kelch13 C580Y mutations on the island of New Guinea bioRxiv. 2019, Aug.
Konstat-Korzenny E, Ascencio-Aragón JE, Niezen-Lugo S et al. Artemisinin and Its Synthetic Derivatives as a Possible Therapy for Cancer. Med Sci (Basel). 2018 Mar; 6(1): 19.
Munyangi J1, Cornet-Vernet L2, Idumbo M3 et al. Artemisia annua and Artemisia afra tea infusions vs. artesunate-amodiaquine (ASAQ) in treating Plasmodium falciparum malaria in a large scale, double blind, randomized clinical trial. Phytomedicine. 2019 Apr;57:49-56.
Elfawal MA, Towler MJ, Reich NG, Weathers PJ, Rich SM.Dried whole-plant Artemisia annua slows evolution of malaria drug resistance and overcomes resistance to artemisinin.Proc Natl Acad Sci U S A. 2015 Jan 20;112(3):821-6.
WHO. Effectiveness of Non-Pharmaceutical Forms of Artemisia annua L. against malaria. Position Statement, 2012.
WHO. Guidelines for the treatment of (uncomplicated) malaria. Third edition, 2015.
Remington L. A serious nightmare: psychiatric and neurologic adverse reactions to mefloquine are serious adverse reactions. Pharmacol Res Perspect. 2017 Aug; 5(4): e00328.
Crutzen B. The malaria business: Big pharma vs natural medicine. 2019-11-01.
https://www.france24.com/en/20190111-reporters-plus-malaria-business-big-pharma-vs-natural-medicine-artemisia-annua-who (hämtad 2019-08-17)
Munyangi J, Cornet-Vernet L, Idumbo M et al. Effect of Artemisia annua and Artemisia afra tea infusions on schistosomiasis in a large clinical trial. Phytomedicine. 2018 Dec;51:233-240.
Rassias DJ, Weathers PJ. Dried leaf Artemisia annua efficacy against non-small cell lung cancer. Phytomedicine. 2019 Jan;52:247-253.

Uråldrig parasit påverkar den moderna människan av Linda Fång, närings- och hälsoskribent

Wellcome Trust Sanger Institute. Multidrug-resistant malaria spreading in Asia: Study reveals importance of genomic surveillance for malaria control strategies. ScienceDaily. ScienceDaily, 23 July 2019.
Miotto O, Sekihara M, Tachibana S-I et al. Emergence of artemisinin-resistant Plasmodium falciparum with kelch13 C580Y mutations on the island of New Guinea bioRxiv. 2019, Aug.
Konstat-Korzenny E, Ascencio-Aragón JE, Niezen-Lugo S et al. Artemisinin and Its Synthetic Derivatives as a Possible Therapy for Cancer. Med Sci (Basel). 2018 Mar; 6(1): 19.
Munyangi J1, Cornet-Vernet L2, Idumbo M3 et al. Artemisia annua and Artemisia afra tea infusions vs. artesunate-amodiaquine (ASAQ) in treating Plasmodium falciparum malaria in a large scale, double blind, randomized clinical trial. Phytomedicine. 2019 Apr;57:49-56.
Elfawal MA, Towler MJ, Reich NG, Weathers PJ, Rich SM.Dried whole-plant Artemisia annua slows evolution of malaria drug resistance and overcomes resistance to artemisinin. Proc Natl Acad Sci U S A. 2015 Jan 20;112(3):821-6.
WHO. Effectiveness of Non-Pharmaceutical Forms of Artemisia annua L. against malaria. Position Statement, 2012.
WHO. Guidelines for the treatment of (uncomplicated) malaria. Third edition, 2015.
Remington L. A serious nightmare: psychiatric and neurologic adverse reactions to mefloquine are serious adverse reactions. Pharmacol Res Perspect. 2017 Aug; 5(4): e00328.
Crutzen B. The malaria business: Big pharma vs natural medicine. 2019-11-01. https://www.france24.com/en/20190111-reporters-plus-malaria-business-big-pharma-vs-natural-medicine-artemisia-annua-who (hämtad 2019-08-17)
Munyangi J, Cornet-Vernet L, Idumbo M et al. Effect of Artemisia annua and Artemisia afra tea infusions on schistosomiasis in a large clinical trial. Phytomedicine. 2018 Dec;51:233-240.
Rassias DJ, Weathers PJ. Dried leaf Artemisia annua efficacy against non-small cell lung cancer. Phytomedicine. 2019 Jan;52:247-253.

Kost och livsstisfaktorer som främjar eller hämmar svampöverväxt av Mikaela Bjerring, näringsterapeut och hälsoskribent

Candidiasis: predisposing factors, prevention, diagnosis and alternative treatment. Mycopathologia. 2014 Jun;177(5-6):223-40. doi: 10.1007/s11046-014-9749-1. Epub 2014 May 1. https://www.ncbi.nlm.nih.gov/pubmed/24789109
The effects of hormonal contraceptives on glycemic regulation. Linacre Q. August, 2014; 81(3): 209–218. doi: 10.1179/2050854914Y.0000000023. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4135453/
Hormone contraceptives and how the body uses carbohydrates in women without diabetes. Published 30 April 2014, Authors: Lopez LM, Grimes DA, Schulz KF. https://www.cochrane.org/CD006133/FERTILREG_hormone-contraceptives-and-how-the-body-uses-carbohydrates-in-women-without-diabetes
Effects of Psychological, Environmental and Physical Stressors on the Gut Microbiota Published online 2018 Sep 11. doi: 10.3389/fmicb.2018.02013 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6143810/
Psychosocial Stress, Cortisol Levels, and Maintenance of Vaginal Health. Published online 2018 Sep 24. doi: 10.3389/fendo.2018.00568. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6165882/
Sleep and Microbes. Published online 2016 Aug 31. doi: 10.1016/bs.irn.2016.07.003 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5441385/
Sleep extension is a feasible lifestyle intervention in free-living adults who are habitually short sleepers: a potential strategy for decreasing intake of free sugars? A randomised controlled pilot study’ is published on Wednesday 10 January 2018 in the American Journal of Clinical Nutrition DOI: 10.1093/ajcn/nqx030 and https://academic.oup.com/ajcn/advance-article/doi/10.1093/ajcn/nqx030/4794751
Disruption of the Gut Ecosystem by Antibiotics. Published online 2017 Nov 29. doi: 10.3349/ymj.2018.59.1.4. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5725362/
Antibiotics destroy immune cells and worsen oral infection. https://thedaily.case.edu/study-antibiotics-destroy-immune-cells-worsen-oral-infection/
Disruption of the Gut Ecosystem by Antibiotics. Published online 2017 Nov 29. doi: 10.3349/ymj.2018.59.1.4. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5725362/
Yeast infection four times as likely with penicillin use. Publish date: August 21, 2013. https://www.mdedge.com/clinicianreviews/article/77427/infectious-diseases/yeast-infection-four-times-likely-penicillin-use
Effects of probiotic bacteria on Candida presence and IgA anti-Candida in the oral cavity of elderly. Braz Dent J. 2012;23(5):534-8. https://www.ncbi.nlm.nih.gov/pubmed/23306230/
A multispecies probiotic reduces oral Candida colonization in denture wearers. J Prosthodont. 2015 Apr;24(3):194-9. doi: 10.1111/jopr.12198. Epub 2014 Aug 20. https://www.ncbi.nlm.nih.gov/pubmed/25143068/
Effect of Probiotic Bacteria on Oral Candida in Frail Elderly. J Dent Res. 2015 Sep;94(9 Suppl):181S-6S. doi: 10.1177/0022034515595950. Epub 2015 Jul 22. https://www.ncbi.nlm.nih.gov/pubmed/26202995/
Antifungal activity of clinical Lactobacillus strains against Candida albicans biofilms: identification of potential probiotic candidates to prevent oral candidiasis. Biofouling. 2018 Feb;34(2):212-225. doi 10.1080/08927014.2018.1425402. Epub 2018 Jan 30. https://www.ncbi.nlm.nih.gov/pubmed/29380647
Purification and partial characterization of novel bacteriocin L23 produced by Lactobacillus fermentum L23. Curr Microbiol. 2008 Apr;56(4):397-402. doi: 10.1007/s00284-007-9094-4. Epub 2008 Jan 3. https://www.ncbi.nlm.nih.gov/pubmed/18172715/
Anti-Candida activity of two-peptide bacteriocins, plantaricins (Pln E/F and J/K) and their mode of action. Fungal Biol. 2014 Feb;118(2):264-75. doi: 10.1016/j.funbio.2013.12.006. Epub 2014 Jan 9. https://www.ncbi.nlm.nih.gov/pubmed/24528647/
Characterization of pentocin TV35b, a bacteriocin-like peptide isolated from Lactobacillus pentosus with a fungistatic effect on Candida albicans. J Appl Microbiol. 1999 Nov;87(5):726-34. https://www.ncbi.nlm.nih.gov/pubmed/10594714/
Production and isolation of reuterin, a growth inhibitor produced by Lactobacillus reuteri. Antimicrob Agents Chemother. 1988 Dec;32(12):1854-8. https://www.ncbi.nlm.nih.gov/pubmed/3245697/
Probiotics Prevent Candida Colonization and Invasive Fungal Sepsis in Preterm Neonates: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Pediatr Neonatol. 2017 Apr;58(2):103-110. doi: 10.1016/j.pedneo.2016.06.001. Epub 2016 Sep 14. https://www.ncbi.nlm.nih.gov/pubmed/27793494
Comparing the Recurrence of Vulvovaginal Candidiasis in Patients Undergoing Prophylactic Treatment with Probiotic and Placebo During the 6 Months. Probiotics Antimicrob Proteins. 2016 Sep;8(3):130-3. doi: 10.1007/s12602-016-9218-x.
Antifungal activities of origanum oil against Candida albicans. Mol Cell Biochem. 2001 Dec;228(1-2):111-7. https://www.ncbi.nlm.nih.gov/pubmed/11855736
Mechanism of Antifungal Activity of Terpenoid Phenols Resembles Calcium Stress and Inhibition of the TOR Pathway. Antimicrob Agents Chemother. 2010 Dec; 54(12): 5062–5069. Published online 2010 Oct 4. doi: 10.1128/AAC.01050-10. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2981246/#r4
Sensitivity of Candida albicans to essential oils: are they an alternative to antifungal agents? J Appl Microbiol. 2016 Dec;121(6):1530-1545. doi: 10.1111/jam.13282. Epub 2016 Oct 24. https://www.ncbi.nlm.nih.gov/pubmed/27568869
Caprylic acid in the effective treatment of intractable medical problems of frequent urination, incontinence, chronic upper respiratory infection, root canalled tooth infection, ALS, etc., caused by asbestos & mixed infections of Candida albicans, Helicobacter pylori & cytomegalovirus with or without other microorganisms & mercury. Acupunct Electrother Res. 2011;36(1-2):19-64. https://www.ncbi.nlm.nih.gov/pubmed/21830350
The Dietary Food Components Capric Acid and Caprylic Acid Inhibit Virulence Factors in Candida albicans Through Multitargeting. J Med Food. 2017 Nov;20(11):1083-1090. doi: 10.1089/jmf.2017.3971. Epub 2017 Sep 18. https://www.ncbi.nlm.nih.gov/pubmed/28922057
Hexosomes with Undecylenic Acid Efficient against Candida albicans. Nanomaterials (Basel). 2018 Feb; 8(2): 91. Published online 2018 Feb 7. doi: 10.3390/nano8020091. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5853723/
Page 68Alternative Medicine ReviewVolume 7, Number 12002Undecylenic Acid. MonographCopyright©2002 Thorne Research, Inc. http://altmedrev.com/archive/publications/7/1/68.pdf
Sugar Sensing and Signaling in Candida albicans and Candida glabrata. Front Microbiol. 2019 Jan 30;10:99. doi: 10.3389/fmicb.2019.00099. eCollection 2019. https://www.ncbi.nlm.nih.gov/pubmed/30761119
Svamp utnyttjar syrebrist för att sprida sig i kroppen. Artikel från Umeå universitet, 23 januari, 2019. https://www.forskning.se/2019/01/23/svamp-utnyttjar-syrebrist-for-att-sprida-sig-i-kroppen/
Production of pyruvate by Candida albicans: proposed role in virulence. FEMS Microbiol Lett. 2000 Sep 1;190(1):35-8. https://www.ncbi.nlm.nih.gov/pubmed/10981686
Evaluation of the relationship between fungal infection, neutrophil leukocytes and macrophages in cervicovaginal smears: Light microscopic examination. J Cytol. 2015 Apr-Jun; 32(2): 79–84. doi: 10.4103/0970-9371.160544. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4520052/
Effect of prolonged modified fasting in obese persons on in vitro markers of immunity: lymphocyte function and serum effects on normal neutrophils. Am J Med Sci. 1990 Jun;299(6):379-85. https://www.ncbi.nlm.nih.gov/pubmed/2356851
Glucose Directly Promotes Antifungal Resistance in the Fungal Pathogen, Candida spp.An external file that holds a picture, illustration, etc. Object name is sbox.jpg. J Biol Chem. 2014 Sep 12; 289(37): 25468–25473. Published online 2014 Jul 22. doi: 10.1074/jbc.C114.571778. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4162151/
Candida sp. Infections in Patients with Diabetes Mellitus. J Clin Med. 2019 Jan; 8(1): 76. Published online 2019 Jan 10. doi: 10.3390/jcm8010076. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352194/

Missing microbes - en orsak till autoimmuna sjukdomar? Nina Törmark, journalist

Human microbiome project: https://hmpdacc.org
Moises hemsida med hans TED-talk: http://www.moisesvm.com
Maskar och Chrohns: https://www.sciencemag.org/news/2016/04/parasitic-worms-may-prevent-crohn-s-disease-altering-bacterial-balance
Läs mer om MS och parasiter: https://www.mstrust.org.uk/a-z/parasitic-worms

Svamp som orsak till vanliga välfärdssjukdomar av Annie Pettersson, fil.mag. (biologi) från Uppsala universitet och fil.dr. (medicin) från Karolinska Institutet

Floreani A, Leung PS, Gershwin ME. Clin Rev Allergy Immunol. 2016 Jun;50(3):287-300. Environmental Basis of Autoimmunity.
Garth L. Nicolson and Jörg Haier. BJMP 2010a;3(1):301. Role of Chronic Bacterial and Viral Infections in Neurodegenerative, Neurobehavioural, Psychiatric, Autoimmune and Fatiguing Illnesses: Part 1
Garth L. Nicolson and Jörg Haier. BJMP 2010b;3(1):301. Role of Chronic Bacterial and Viral Infections in Neurodegenerative, Neurobehavioural, Psychiatric, Autoimmune and Fatiguing Illnesses: Part 2
Lei Yan, Chunhui Yang, Jianguo Tang. Microbiological Research. Volume 168, Issue 7, 25 August 2013, Pages 389-395. Review Article. Disruption of the intestinal mucosal barrier in Candida albicans infections
Tsavkelova E.A., Botvinko I.V., Kudrin V.S., Oleskin A.V. Detection of neurotransmitter amines in microorganisms with the use of high-performance liquid chromatography. Dokl. Biochem. Proc. Acad. Sci. USSR Biochem. Sect. 2000;372:115–117.
Cryan J. F., Dinan T. G. (2012). Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour. Nat. Rev. Neurosci. 13 701–712. 10.1038/nrn3346
Voropaeva E.A. Resistance to antibiotics and histamine production at the bacteria, isolated from the stomatopharynx of the children with bronchial asthma. Antibiot. Khimioterapiia Antibiot. Chemoterapy Sic. 2002;47:8–13.
Parady B. J Alzheimers Dis Rep. 2018; 2(1): 139–152. Published online 2018 Aug 1. Innate Immune and Fungal Model of Alzheimer’s Disease
Claudia Jiménez-López and Michael C. Lorenz. PLoS Pathog. 2013 Nov; 9(11): e1003741. Fungal Immune Evasion in a Model Host–Pathogen Interaction: Candida albicans Versus Macrophages
Alessandra da Silva Dantas, Kathy K Lee, Ingrida Raziunaite, Katja Schaefer, Jeanette Wagener, Bhawna Yadav, Neil ARGow. Current Opinion in Microbiology. Volume 34, December 2016, Pages 111-118. Cell biology of Candida albicans–host interactions
Citiulo F, Jacobsen ID, Miramón P, Schild L, Brunke S, Zipfel P, Brock M, Hube B, Wilson D. PLoS Pathog. 2012;8(6):e1002777. Candida albicans scavenges host zinc via Pra1 during endothelial invasion.
Ranjan A, Dongari-Bagtzoglou A. J Fungi (Basel). 2018 Sep 18;4(3). pii: E112. Tipping the Balance: C. albicans Adaptation in Polymicrobial Environments.
Giorgia Renga, Silvia Moretti, Vasilis Oikonomou, Monica Borghi, Teresa Zelante, Giuseppe Paolicelli, Claudio Costantini, Marco De Zuani, Valeria Rachela Villella, Valeria Raia, Rachele Del Sordo, Andrea Bartoli, Monia Baldoni, Jean-Christophe Renauld, Angelo Sidoni, Enrico Garaci, Luigi Maiuri, Carlo Pucillo, and Luigina Romani. Cell Rep. 2018 May 8; 23(6): 1767–1778. IL-9 and Mast Cells Are Key Players of Candida albicans Commensalism and Pathogenesis in the Gut
Matthew L. Wheeler, Jose J. Limon, Agnieszka S. Bar, Christian A. Leal, Matthew Gargus, Jie Tang, Jordan Brown, Vincent A. Funari, Hanlin L. Wang, Timothy Crother, Moshe Arditi, David M. Underhill and Iliyan D. Iliev. Cell Host Microbe. Cell Host Microbe. 2016 Jun 8; 19(6): 865–873. Immunological Consequences of Intestinal Fungal Dysbiosis
Sokol H., Leducq V., Aschard H., Pham H.-P., Jegou S., Landman C., Cohen D., Liguori G., Bourrier A., Nion-Larmurier I., et al. Fungal microbiota dysbiosis in IBD. Gut. 2017;66:1039–1048.
Hager CL, Ghannoum MA. Dig Liver Dis. 2017 Nov;49(11):1171-1176. The mycobiome: Role in health and disease, and as a potential probiotic target in gastrointestinal disease.
Liguori G, Lamas B, Richard ML, Brandi G, da Costa G, Hoffmann TW, Di Simone MP, Calabrese C, Poggioli G, Langella P, Campieri M, Sokol H. J Crohns Colitis. 2016 Mar;10(3):296-305. Fungal Dysbiosis in Mucosa-associated Microbiota of Crohn's Disease Patients.
Miyoshi J, Sofia MA, Pierre JF. Clin J Gastroenterol. 2018 Dec;11(6):449-456. The evidence for fungus in Crohn's disease pathogenesis.
Wcislo-Zwolinska, Malgorzata, et al. Gastroenterology, vol. 134, no. 4, 2008. W1783 Effect of Combined Antifungeal and Probiotic Therapy On Candida Colonization of Human Ulcerative Colitis and the Healing of Colonic Injury in Experimental Animal Model of Colitis Ulcerosa.
Zwolinska-Wcislo M, Brzozowski T, Budak A, Kwiecien S, Sliwowski Z, Drozdowicz D, Trojanowska D, Rudnicka-Sosin L, Mach T, Konturek SJ, Pawlik WW. J Physiol Pharmacol. 2009 Mar;60(1):107-18. Effect of Candida colonization on human ulcerative colitis and the healing of inflammatory changes of the colon in the experimental model of colitis ulcerosa.
Botschuijver S, Roeselers G, Levin E, Jonkers DM, Welting O, Heinsbroek SEM, de Weerd HH, Boekhout T, Fornai M, Masclee AA, Schuren FHJ, de Jonge WJ, Seppen J, van den Wijngaard RM. Gastroenterology. 2017 Oct;153(4):1026-1039. Intestinal Fungal Dysbiosis Is Associated With Visceral Hypersensitivity in Patients With Irritable Bowel Syndrome and Rats.
Böhringer M, Pohlers S, Schulze S, Albrecht-Eckardt D, Piegsa J, Weber M, Martin R, Hünniger K, Linde J, Guthke R, Kurzai O. Cell Microbiol. 2016 Jul;18(7):889-904. Candida albicans infection leads to barrier breakdown and a MAPK/NF-κB mediated stress response in the intestinal epithelial cell line C2BBe1.
Raphaël Enaud, Louise-Eva Vandenborght, Noémie Coron, Thomas Bazin, Renaud Prevel, Thierry Schaeverbeke, Patrick Berger, Michael Fayon, Thierry Lamireau, and Laurence Delhaes. Microorganisms. 2018 Mar; 6(1): 22. The Mycobiome: A Neglected Component in the Microbiota-Gut-Brain Axis
Alonso R, Pisa D, Fernández-Fernández AM, Rábano A, Carrasco L. Neurobiol Dis. 2017 Dec;108:249-260. Fungal infection in neural tissue of patients with amyotrophic lateral sclerosis.
Francesco Strati, Duccio Cavalieri, Davide Albanese, Claudio De Felice, Claudio Donati, Joussef Hayek, Olivier Jousson, Silvia Leoncini, Daniela Renzi, Antonio Calabrò, and Carlotta De Filippo. Microbiome. 2017; 5: 24. New evidences on the altered gut microbiota in autism spectrum disorders
Severance EG, Yolken RH. Curr Top Behav Neurosci. 2019 Mar 8. From Infection to the Microbiome: An Evolving Role of Microbes in Schizophrenia.
Alonso R, Fernández-Fernández AM, Pisa D, Carrasco L. Neurobiol Dis. 2018 Sep;117:42-61. Multiple sclerosis and mixed microbial infections. Direct identification of fungi and bacteria in nervous tissue.
Epp LM, Mravec B. Bratisl Lek Listy. 2006;107(6-7):227-30. Chronic polysystemic candidiasis as a possible contributor to onset of idiopathic Parkinson's disease.
Severance EG, Gressitt KL, Stallings CR, Katsafanas E, Schweinfurth LA, Savage CLG, Adamos MB, Sweeney KM, Origoni AE, Khushalani S, Dickerson FB, Yolken RH. Brain Behav Immun. 2017 May;62:41-45. Probiotic normalization of Candida albicans in schizophrenia: A randomized, placebo-controlled, longitudinal pilot study.
Logsdon AF, Erickson MA, Rhea EM, Salameh TS, Banks WA. Exp Biol Med (Maywood). 2018 Jan;243(2):159-165. Gut reactions: How the blood-brain barrier connects the microbiome and the brain.
Wu Y, Du S, Johnson JL, Tung HY, Landers CT, Liu Y, Seman BG, Wheeler RT Costa-Mattioli M Kheradmand F, Zheng H, Corry DB. Nat Commun. 2019 Jan 4;10(1):58. Microglia and amyloid precursor protein coordinate control of transient Candida cerebritis with memory deficits.
Jong, A. Y., Stins, M. F., Huang, S.-H., Chen, S. H. & Kim, K. S. Infect. Immun. 69, 4536–4544 (2001). Traversal of Candida albicans across human blood-brain barrier in vitro.
Robert D.Moir, Richard Lathe, Rudolph E. Tanzia. Alzheimer's & Dementia. Volume 14, Issue 12, December 2018, Pages 1602-1614. The antimicrobial protection hypothesis of Alzheimer's disease
Spitzer P, Mateja Condic, Martin Herrmann, Timo Jan Oberstein, Marina Scharin-Mehlmann, Daniel F. Gilbert, Oliver Friedrich, Teja Grömer, Johannes Kornhuber, Roland Lang, and Juan Manuel Maler. Sci Rep. 2016; 6: 32228. Amyloidogenic amyloid-β-peptide variants induce microbial agglutination and exert antimicrobial activity
Alonso R, Pisa D, Aguado B, Carrasco L.J Alzheimers Dis. 2017;58(1):55-67. Identification of Fungal Species in Brain Tissue from Alzheimer's Disease by Next-Generation Sequencing.

Nr 5, 2019: Kollagen

Kaffe - den älskade svarta drycken, Pia Andra, hälsoskribent

Kollagen - ett tillskott för hud, skelett, senor och leder, Jonas Bergqvist, leg sjukgymnast, utbildare

Marlyn Wu; Jonathan S. Crane; Biochemistry, Collagen Synthesis; 2018
Mienaltowski MJ & Birk DE; Structure, physiology, and biochemistry of collagens; Adv Exp Med Biol. 2014;802:5-29.
Vieira CP et al; Glycine improves biochemical and biomechanical properties following inflammation of the achilles tendon; Anat Rec (Hoboken). 2015 Mar;298(3):538-45.
Franceschi RT et al; Effects of ascorbic acid on collagen matrix formation and osteoblast differentiation in murine MC3T3-E1 cells. J Bone Miner Res. 1994 Jun;9(6):843-54.
Ganta DR et al; Ascorbic acid alters collagen integrins in bone culture; Endocrinology. 1997 Sep;138(9):3606-12.
Harada S et al; Role of ascorbic acid in the regulation of proliferation in osteoblast-like MC3T3-E1 cells; J Bone Miner Res. 1991 Sep;6(9):903-8.
DePhillipo N N et al; Efficacy of Vitamin C Supplementation on Collagen Synthesis and Oxidative Stress After Musculoskeletal Injuries: A Systematic Review; Orthop J Sports Med. 2018 Oct 25;6(10):2325967118804544; 2018 Oct.
Figueres Juher T et al; An overview of the beneficial effects of hydrolysed collagen intake on joint and bone health and on skin ageing; Nutr Hosp. 2015 Jul 18;32 Suppl 1:62-6
Asserin J et al; The effect of oral collagen peptide supplementation on skin moisture and the dermal collagen network: evidence from an ex vivo model and randomized, placebo-controlled clinical trials; J Cosmet Dermatol. 2015 Dec;14(4):291-301.
10. McAlindon TE et al; Change in knee osteoarthritis cartilage detected by delayed gadolinium enhanced magnetic resonance imaging following treatment with collagen hydrolysate: a pilot randomized controlled trial; Osteoarthritis Cartilage. 2011 Apr;19(4):399-405.
Langberg H et al; Training-induced changes in peritendinous type I collagen turnover determined by microdialysis in humans; J Physiol. 2001 Jul 1;534(Pt 1):297-302.
Miller BF et al; ; Tendon collagen synthesis at rest and after exercise in women; J Appl Physiol (1985). 2007 Feb;102(2):541-6.
Heinemeier KM et al; Effect of unloading followed by reloading on expression of collagen and related growth factors in rat tendon and muscle; J Appl Physiol (1985). 2009 Jan;106(1):178-86.
Couppé C et al; Habitual loading results in tendon hypertrophy and increased stiffness of the human patellar tendon. J Appl Physiol (1985). 2008 Sep;105(3):805-10.
Shaw G et al; Vitamin C-enriched gelatin supplementation before intermittent activity augments collagen synthesis; Am J Clin Nutr. 2017 Jan;105(1):136-143.
Clark KL et al; 24-Week study on the use of collagen hydrolysate as a dietary supplement in athletes with activity-related joint pain; Curr Med Res Opin. 2008 May;24(5):1485-96.

Kollagenets betydelse för ledhälsan, Mikaela Bjerring, näringsterapeut och hälsoskribent

(1) Kollagen gav god effekt vid knäartros: http://www.ncbi.nlm.nih.gov/pubmed/26822714

(2) Safety and efficacy of undenatured type II collagen in the treatment of osteoarthritis of the knee: a clinical trial: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2764342

(3) Effects of oral administration of type II collagen on rheumatoid arthritis: https://www.ncbi.nlm.nih.gov/pubmed/8378772

(4) 24-Week study on the use of collagen hydrolysate as a dietary supplement in athletes with activity-related joint pain: https://www.ncbi.nlm.nih.gov/pubmed/18416885

(5) Efficacy of specific bioactive collagen peptides in the treatment of joint pain: https://www.oarsijournal.com/article/S1063-4584(16)00389-7/abstract

(6) L-Glycine: a novel antiinflammatory, immunomodulatory, and cytoprotective agent: https://www.ncbi.nlm.nih.gov/pubmed/12589194

C-vitamin för en frisk bindväv, Nina Törmark, journalist

1. Skörbjugg i USA https://www.sciencealert.com/scurvy-coming-back-vitamin-c-poverty-massachusetts-boston-vitamania-movie

2. C-vitaminbrist bland svårt sjuka https://www.ncbi.nlm.nih.gov/pubmed/20018480

3. Skörbjugg hos barn med autism https://www.ncbi.nlm.nih.gov/pubmed/26590972

4. Parodontos C-vitaminbrist https://www.ncbi.nlm.nih.gov/pmc/articles/PMC193894/ och https://www.livestrong.com/article/521960-how-much-vitamin-c-to-take-for-periodontal-disease/

5: EFSA https://www.efsa.europa.eu/en/efsajournal/pub/3257.

6. Positiva effekter av kollagen https://www.ncbi.nlm.nih.gov/pubmed/30681787

7. Kisel https://www.ncbi.nlm.nih.gov/pubmed/27548886

8. Histidin https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5634381/

9. Livsmedelsverket: https://www.livsmedelsverket.se/livsmedel-och-innehall/naringsamne/livsmedelsdatabasen

Kollagen - kan det spela roll vid diabetes och dess följdsjukdomar, Anette Lindqvist, näringsmedicinare, skribent

1. Paul RG, Bailey AJ. Glycation of collagen: the basis of its central role in the late complications of ageing and diabetes. Int J Biochem Cell Biol. 1996 Dec;28 (12):1297-310. https://www.ncbi.nlm.nih.gov/pubmed/9022289

2 . Richard Yan-Do Patrick E. MacDonald Impaired “Glycine”-mia in Type 2 Diabetes and Potential Mechanisms Contributing to Glucose Homeostasis Endocrinology, Volume 158, Issue 5, 1 May 2017, Pages 1064–1073, https://academic.oup.com/endo/article/158/5/1064/3070537

3. Gannon MC1, Nuttall JA, Nuttall FQ. Metabolic Research Laboratory and the Section of Endocrinology, Metabolism, and Nutrition, Minneapolis VA Medical Center, University of Minnesota, Minneapolis 55417, USA. ganno004@tc.umn.edu The metabolic response to ingested glycine.
Am J Clin Nutr. 2002 Dec;76(6):1302-7. https://www.ncbi.nlm.nih.gov/pubmed/12450897

4 (1). Ericson E & Ericson T (2012) Medicinska sjukdomar. Studentlitteratur Lund. https://www.hjart-lung.se/vart-arbete/tidningen-status/artiklar/darfor-okar-diabetes-risken-for-hjart-karlsjukdom/

4 (2). Edsfeldt A1, Gonçalves I2, Grufman H2, Nitulescu M2, Dunér P2, Bengtsson E2, Mollet IG2, Persson A2, Nilsson M2, Orho-Melander M2, Melander O2, Björkbacka H2, Nilsson J2. Impaired fibrous repair: a possible contributor to atherosclerotic plaque vulnerability in patients with type II diabetes. Arterioscler Thromb Vasc Biol. 2014 Sep;34(9):2143-50. doi https://www.ncbi.nlm.nih.gov/pubmed/25035341

5. Diabets portalen, Lunds universitet. https://www.diabetesportalen.lu.se/forskning/avhandlingar/2013/att-upptacka-sarbara-plack

Övriga Källor

https://www.ncbi.nlm.nih.gov/pubmed/25035341

http://www.lakartidningen.se/Functions/OldArticleView.aspx?articleId=8397

https://www.diabetes.fi/sv/diabetesforbundet_i_finland/om_diabetes

http://publikdocplus.regionuppsala.se/Home/GetDocument?containerName=e0c73411-be4b-4fee-ac09-640f9e2c5d83&reference=DocPlusSTYR-14234&docId=DocPlusSTYR-14234

http://www.kollagen.nu/mat

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3951818/

https://www.furtherfood.com/collagen-protein-stabilize-blood-sugar-diabetes-restore-collagen-production-diabetics/

Minska nedbrytningen av kollagen med fytonäringsämnen, Lina Åhlén, BSc Nutritional Science

1. Chang S-W, Buehler M.J. Molecular biomechanics of collagen molecules. Materials Today. 2014;17:2

2. Pittayapruek P., Meephansan J., Prapapan O. et.al. Role of Matrix Metalloproteinases in Photoaging and Photocarcinogenesis. International Journal of Molecular Science. 2016;17:6.

3. Christie S., Walker A.F., Hicks S.M., Abeyasekera S. Flavonoid supplement improves leg health and reduces fluid retention in pre-menopausal women in a double-blind, placebo-controlled study. Phytomedicine. 2004;11:1

4. Christie, S., Barlow, A. et al. (eds.) (2012) Colladeen Study (LOTCOL I and II) Lamberts Healthcare Ltd.; Aspen Clinical Research, Maldon, Essex, UK

5. Bae J.Y., Lim S.S., Kim S.J. et al. Bog blueberry anthocyanins alleviate photoaging in ultraviolet-B irradiation-induced human dermal fibroblasts Molecular Nutrition & Food Research. 2009;53:6

6. Matchett M.D., MacKinnon S.L., Sweeney M.I., et.al. Blueberry flavonoids inhibit matrix metalloproteinase activity in DU145 human prostate cancer cells. Biochemistry and Cell Biology 2005;83:5

7. Du C., Smith A., Avalos M. et.al. Blueberries Improve Pain, Gait Performance, and Inﬂammation in Individuals with Symptomatic Knee Osteoarthritis. Nutrients. 2019;11:290

8. Roh E., Kim J-E., Kwon J.Y. et.al. Molecular mechanisms of green tea polyphenols with protective effects against skin photoaging. Critical Reviews in Food Science and Nutrition. 2017;57:8

9. Nichols J.A, Katiyar S.K. Skin photoprotection by natural polyphenols: anti-inflammatory, antioxidant and DNA repair mechanisms. Archives of Dermatol Research. 2010;302:2

10. Vayalil P.K., Mittal A., Hara Y. et.al. Green Tea Polyphenols Prevent Ultraviolet Light-Induced Oxidative Damage and Matrix Metalloproteinases Expression in Mouse Skin. Journal of Investigative Dermatology. 2004;122:6

11. Lephart E.D., Sommerfeldt J.M., Andrus M.B. Resveratrol: inﬂuences on gene expression in human skin. Journal of Functional Foods. 2014;10

12. Offord E.A et.al. Photoprotective potential of lycopene, beta-carotene, vitamin E, vitamin C and carnosic acid in UVA-irradiated human skin fibroblasts. Free radical biology and medicine. 2002; 32:12

Nr 4, 2019: Matsmältning

Spännande smaker med god näring, Pia Andrea, hälsoskribent

1. https://www.amazon.com/Homesteading-Handbook-vol-Food-Drying/dp/1500669946

2. https://products.mercola.com/fermented-beet-powder/

3. https://products.mercola.com/fermented-beet-powder/

4. https://nourishedkitchen.com/green-veggie-powder/

5. https://healthyeating.sfgate.com/calories-dried-vegetables-3798.html

6. https://www.livestrong.com/article/340760-nutritional-value-of-dehydrated-vegetables/

7. https://extension2.missouri.edu/gh1562

8. https://www.amazon.com/Homesteading-Handbook-vol-Food-Drying/dp/1500669946

9. https://www.amazon.com/Homesteading-Handbook-vol-Food-Drying/dp/1500669946

Människans artriktiga kost, Jonas Bergqvist, leg sjukgymnast, utbildare

1. Fumagalli Matteo et al; Greenlandic Inuit show genetic signatures of diet and climate adaptation; Science 18 September 2015: Vol. 349 no. 6254 pp. 1343-1347

2. Roseboom TJ; Effects of prenatal exposure to the Dutch famine on adult disease in later life: an overview; Molecular and Cellular Endocrinology 185 (2001) 93–98

3. Henry AG, Brooks AS, Piperno DR. Microfossils in calculus demonstrate consumption of plants and cooked foods in Neanderthal diets. Proc Natl Acad Sci U S A. 2011 Jan 11;108(2):486-91

Så påverkas din matsmältning av stress, Mikaela Bjerring, näringsterapeut, hälsoskribent

1. Effects of occupational stress on the gastrointestinal tract: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3829457/

2. The Effect of Emotional Stress and Depression on the Prevalence of Digestive Diseases: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4398234/

3. The bowel and beyond: the enteric nervous system in neurological disorders: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5005185/

4. Stress and the sensitive gut: https://www.health.harvard.edu/newsletter_article/stress-and-the-sensitive-gut

5. Enzyme Science: https://enzyscience.com/pages/enzyme-faq

6. Neural and Hormonal Regulation of Pancreatic Secretion: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2838392/

7. Stress, Food, and Inflammation: Psychoneuroimmunology and Nutrition at the Cutting Edge: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2868080/

8. Introduction to the human gut microbiota: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5433529/

9. Gut microbiota functions: metabolism of nutrients and other food components: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5847071/

10. Stress & the gut-brain axis: Regulation by the microbiome: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5736941/

11. Stress at the intestinal surface: catecholamines and mucosa-bacteria interactions: https://www.ncbi.nlm.nih.gov/pubmed/20941511

12. The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4367209/

13. Stress and the gut: Pathophysiology, clinic consequences, diagnostic approach and treatment option http://www.jpp.krakow.pl/journal/archive/12_11/pdf/591_12_11_article.pdf

14. Stressor Exposure Disrupts Commensal Microbial Populations in the Intestines and Leads to Increased Colonization by Citrobacter rodentium: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2849416/

15. Exposure to a Social Stressor Alters the Structure of the Intestinal Microbiota: Implications for Stressor-Induced Immunomodulation: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3039072/

16. Stress and the gut: pathophysiology, clinical consequences, diagnostic approach and treatment options: https://www.ncbi.nlm.nih.gov/pubmed/22314561

17. Stress and the gut: Pathophysiology, clinic consequences, diagnostic approach and treatment option http://www.jpp.krakow.pl/journal/archive/12_11/pdf/591_12_11_article.pdf

18. How Stress Contributes to SIBO: https://kresserinstitute.com/how-stress-contributes-to-sibo/

19. Gut Pathogens: https://gutpathogens.biomedcentral.com/articles/10.1186/1757-4749-3-1

PPI - medicin med sur eftersmak, Linus Mårtensson, leg läkare, specialist i allmänmedicin

1. Agréus MS. Sjukdomar i matstrupe, magsäck och tolvfingertarm | Läkemedelsboken [Internet]. [cited 2019 Mar 27]. Available from: https://lakemedelsboken.se/kapitel/mage-tarm/sjukdomar_i_matstrupe_magsack_och_tolvfingertarm.html

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3. Lindström E, Chen D, Norlén P, Andersson K, Håkanson R. Control of gastric acid secretion:the gastrin-ECL cell-parietal cell axis. Comp Biochem Physiol, Part A Mol Integr Physiol. 2001 Mar;128(3):505–14.

4. Smith JL. The role of gastric acid in preventing foodborne disease and how bacteria overcome acid conditions. J Food Prot. 2003 Jul;66(7):1292–303.

5. Tennant SM, Hartland EL, Phumoonna T, Lyras D, Rood JI, Robins-Browne RM, et al. Influence of gastric acid on susceptibility to infection with ingested bacterial pathogens. Infect Immun. 2008 Feb;76(2):639–45.

6. Zhu H, Hart CA, Sales D, Roberts NB. Bacterial killing in gastric juice--effect of pH and pepsin on Escherichia coli and Helicobacter pylori. J Med Microbiol. 2006 Sep;55(Pt 9):1265–70.

7. Parasa S, Sharma P. Complications of gastro-oesophageal reflux disease. Best Pract Res Clin Gastroenterol. 2013 Jun;27(3):433–42.

8. Miwa H, Kondo T, Oshima T, Fukui H, Tomita T, Watari J. Esophageal sensation and esophageal hypersensitivity - overview from bench to bedside. J Neurogastroenterol Motil. 2010 Oct 30;16(4):353–62.

9. Sharp GS, Fister HW. The diagnosis and treatment of achlorhydria: ten-year study. J Am Geriatr Soc. 1967 Aug;15(8):786–91.

10. Boeckxstaens GE. The lower oesophageal sphincter. Neurogastroenterol Motil. 2005 Jun;17 Suppl 1:13–21.

11. Diamant NE. Pathophysiology of gastroesophageal reflux disease. GI Motility online. 2006 May 16;

12. Holloway RH, Dent J. Pathophysiology of gastroesophageal reflux. Lower esophageal sphincter dysfunction in gastroesophageal reflux disease. Gastroenterol Clin North Am. 1990 Sep;19(3):517–35.

13. Navarro-Rodriguez T, Hashimoto CL, Carrilho FJ, Strauss E, Laudanna AA, Moraes-Filho JPP. Reduction of abdominal pressure in patients with ascites reduces gastroesophageal reflux. Dis Esophagus. 2003 Jun 1;16(2):77–82.

14. The Real Reasons for GERD: What You Need To Know | Sepalika [Internet]. [cited 2019 Mar 30]. Available from: https://www.sepalika.com/gerd/why-gerd-happens/

15. Rumessen JJ. Hydrogen and methane breath tests for evaluation of resistant carbohydrates. Eur J Clin Nutr. 1992 Oct;46 Suppl 2:S77-90.

16. Nasser SC, Slim M, Nassif JG, Nasser SM. Influence of proton pump inhibitors on gastritis diagnosis and pathologic gastric changes. World J Gastroenterol. 2015 Apr 21;21(15):4599–606.

17. Li Z, Wu C, Li L, Wang Z, Xie H, He X, et al. Effect of long-term proton pump inhibitor administration on gastric mucosal atrophy: A meta-analysis. Saudi J Gastroenterol. 2017 Aug;23(4):222–8.

18. Marcuard SP, Albernaz L, Khazanie PG. Omeprazole therapy causes malabsorption of cyanocobalamin (vitamin B12). Ann Intern Med. 1994 Feb 1;120(3):211–5.

19. Howden CW. Vitamin B12 levels during prolonged treatment with proton pump inhibitors. J Clin Gastroenterol. 2000 Jan;30(1):29–33.

20. Jacobs A, Lawrie JH, Entwistle CC, Campbell H. Gastric acid secretion in chronic iron-deficiency anaemia. Lancet. 1966 Jul;288(7456):190–2.

21. Bezwoda W, Charlton R, Bothwell T, Torrance J, Mayet F. The importance of gastric hydrochloric acid in the absorption of nonheme food iron. The Journal of Laboratory and Clinical Medicine [Internet]. 1978 Jul 1 [cited 2019 Mar 27];92(1):108–16. Available from: https://www.translationalres.com/article/0022-2143(78)90074-4/abstract

22. Henderson LM, Brewer GJ, Dressman JB, Swidan SZ, DuRoss DJ, Adair CH, et al. Effect of intragastric pH on the absorption of oral zinc acetate and zinc oxide in young healthy volunteers. JPEN J Parenter Enteral Nutr. 1995 Oct;19(5):393–7.

23. Champagne ET. Low gastric hydrochloric acid secretion and mineral bioavailability. Adv Exp Med Biol. 1989;249:173–84.

24. Omeprazol Apofri - FASS Vårdpersonal [Internet]. [cited 2019 Mar 30]. Available from: https://www.fass.se/LIF/product?userType=0&nplId=20100227000013

25. Lombardo L, Foti M, Ruggia O, Chiecchio A. Increased incidence of small intestinal bacterial overgrowth during proton pump inhibitor therapy. Clin Gastroenterol Hepatol. 2010 Jun;8(6):504–8.

26. Theisen J, Nehra D, Citron D, Johansson J, Hagen JA, Crookes PF, et al. Suppression of gastric acid secretion in patients with gastroesophageal reflux disease results in gastric bacterial overgrowth and deconjugation of bile acids. J Gastrointest Surg. 4(1):50–4.

27. Pounder RE, Ng D. The prevalence of Helicobacter pylori infection in different countries. Aliment Pharmacol Ther. 1995;9 Suppl 2:33–9.

28. El-Omar EM, Oien K, El-Nujumi A, Gillen D, Wirz A, Dahill S, et al. Helicobacter pylori infection and chronic gastric acid hyposecretion. Gastroenterology. 1997 Jul;113(1):15–24.

29. Vannella L, Lahner E, Annibale B. Risk for gastric neoplasias in patients with chronic atrophic gastritis: a critical reappraisal. World J Gastroenterol. 2012 Mar 28;18(12):1279–85.

30. Cheung DY. Atrophic gastritis increases the risk of gastric cancer in asymptomatic population in korea. Gut Liver. 2017 Sep 15;11(5):575–6.

31. Brusselaers N, Wahlin K, Engstrand L, Lagergren J. Maintenance therapy with proton pump inhibitors and risk of gastric cancer: a nationwide population-based cohort study in Sweden. BMJ Open. 2017 Oct 30;7(10):e017739.

32. Mattsson JP, Väänänen K, Wallmark B, Lorentzon P. Omeprazole and bafilomycin, two proton pump inhibitors: differentiation of their effects on gastric, kidney and bone H(+)-translocating ATPases. Biochim Biophys Acta. 1991 Jun 18;1065(2):261–8.

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36. Charlot M, Ahlehoff O, Norgaard ML, Jørgensen CH, Sørensen R, Abildstrøm SZ, et al. Proton-pump inhibitors are associated with increased cardiovascular risk independent of clopidogrel use: a nationwide cohort study. Ann Intern Med. 2010 Sep 21;153(6):378–86.

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40. Akter S, Hassan MR, Shahriar M, Akter N, Abbas MG, Bhuiyan MA. Cognitive impact after short-term exposure to different proton pump inhibitors: assessment using CANTAB software. Alzheimers Res Ther. 2015 Dec 27;7:79.

41. Laudisio A, Antonelli Incalzi R, Gemma A, Giovannini S, Lo Monaco MR, Vetrano DL, et al. Use of proton-pump inhibitors is associated with depression: a population-based study. Int Psychogeriatr. 2018;30(1):153–9.

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51. Kinoshita Y, Ishimura N, Ishihara S. Advantages and Disadvantages of Long-term Proton Pump Inhibitor Use. J Neurogastroenterol Motil. 2018 Apr 30;24(2):182–96.

Nr 5, 2019: Funktionsmedicin

Är det slut för den gröna trenden?, Pia Andrea hälsoskribent

1. https://www.youtube.com/watch?feature=youtu.be&v=j3TT0N0eXwo&fbclid=IwAR3tvlsZsmjRcxPZA4k7QU-0ol1GmbGhv23gkW8P-gcuTHfu2RsHrm_p0_A&app=desktop

2. https://namedprogram.com/elimination-of-oxalates-for-post-traumatic-stress-disorder/

3. https://www.healthline.com/health/what-is-a-low-oxalate-diet

4. https://www.youtube.com/watch?feature=youtu.be&v=j3TT0N0eXwo&fbclid=IwAR3tvlsZsmjRcxPZA4k7QU-0ol1GmbGhv23gkW8P-gcuTHfu2RsHrm_p0_A&app=desktop

5. https://www.youtube.com/watch?v=fFF55stxVIw&list=PLXRAr-zqLf7NOnKyfUfYR0BOiu2Y1XXAw

6. https://www.youtube.com/watch?v=fFF55stxVIw&list=PLXRAr-zqLf7NOnKyfUfYR0BOiu2Y1XXAw

7. https://www.youtube.com/watch?v=fFF55stxVIw&list=PLXRAr-zqLf7NOnKyfUfYR0BOiu2Y1XXAw

8. https://www.youtube.com/watch?v=fFF55stxVIw&list=PLXRAr-zqLf7NOnKyfUfYR0BOiu2Y1XXAw

9. https://drjockers.com/low-oxalate-diet/

10. https://drjockers.com/low-oxalate-diet/

11. https://drjockers.com/low-oxalate-diet/

12. https://drjockers.com/low-oxalate-diet/

13. https://www.mindbodygreen.com/0-25765/are-green-juices-smoothies-actually-healthy-a-cardiologist-explains.html

14. https://www.youtube.com/watch?v=xqUO4P9ADI0&feature=youtu.be&fbclid=IwAR0ksi10ibRbHVmQeAnHqj9oF7yaxGO5mrmPDO_mYpskDjuVksm90TT_LcE

15. https://my.clevelandclinic.org/health/articles/11066-kidney-stones-oxalate-controlled-diet

16. https://www.healthline.com/nutrition/oxalate-good-or-bad#section8

Funktionsmedicin - ett paradigmskifte på gång, Peter Martin, leg.läkare, med dr.

1. Rappaport, 2016.

2. Nielsen J, 2017.

3. Hanaway, 2016

4. Chung et al, 2013.

5. Chung et al. Nutrition education in European medical schools: results of an international survey. European Journal of Clinical Nutrition (2014) 68, 844–846

6. Hanaway P. Form Follows Function: A Functional Medicine Overview Perm J 2016 Fall;20(4):16-109

7. Loscalzo J and Barabasi A-L. Systems Biology and the Future of Medicine. Wiley Interdiscip Rev Syst Biol Med . 2011 November ; 3(6): 619–627

8. Nielsen J. Systems Biology of Metabolism. Annual Review of Biochemistry. Vol. 86:245-275

9. Rappaport SM (2016) Genetic Factors Are Not the Major Causes of Chronic Diseases. PLoS ONE 11(4)

Människans artriktiga kost, Jonas Bergqvist, leg sjukgymnast, utbildare

1. Fumagalli Matteo et al; Greenlandic Inuit show genetic signatures of diet and climate adaptation; Science 18 September 2015: Vol. 349 no. 6254 pp. 1343-1347

2. Roseboom TJ; Effects of prenatal exposure to the Dutch famine on adult disease in later life: an overview; Molecular and Cellular Endocrinology 185 (2001) 93–98

3. Henry AG, Brooks AS, Piperno DR. Microfossils in calculus demonstrate consumption of plants and cooked foods in Neanderthal diets. Proc Natl Acad Sci U S A. 2011 Jan 11;108(2):486-91

Alltid trött? Funktionsmedicin kan ge dig svaren, Mikaela Bjerring, näringsterapeut och hälsoskribent

1. The Putative Role of Viruses, Bacteria, and Chronic Fungal Biotoxin Exposure in the Genesis of Intractable Fatigue Accompanied by Cognitive and Physical Disability. https://www.ncbi.nlm.nih.gov/pubmed/26081141

2. Naik E, Dixit VM. Mitochondrial reactive oxygen species drive proinflammatory cytokine production. J Exp Med. 2011 Mar 14;208(3):417-20.

3. Spence VA, Kennedy G, Belch JJ, Hill A, Khan F. Low-grade inflammation and arterial wave reflection in patients with chronic fatigue syndrome. Clin Sci (Lond). 2008 Apr;114(8):561-6.

4. Raison CL, Lin JM, Reeves WC. Association of peripheral inflammatory markers with chronic fatigue in a population-based sample. Brain Behav Immun. 2009 Mar;23(3):327-37.

5. Brinkley TE, Leng X, et al. Chronic inflammation is associated with low physical function in older adults across multiple comorbidities. J Gerontol A Biol Sci Med Sci. 2009 Apr;64(4):455-61.

6. Christian LM, Glaser R, et al. Poorer self-rated health is associated with elevated inflammatory markers among older adults. Psychoneuroendocrinology. 2011 Nov;36(10):1495-504.

7. Chronic fatigue syndrome 5 years after giardiasis: differential diagnoses, characteristics and natural course. https://www.ncbi.nlm.nih.gov/pubmed/23399438

8. Increased number of Candida albicans in the faecal microflora of chronic fatigue syndrome patients during the acute phase of illness. https://www.ncbi.nlm.nih.gov/pubmed/17886123

9. Non-celiac gluten sensitivity and rheumatic diseases https://www.ncbi.nlm.nih.gov/pubmed/25956352

10. Effect of folic acid and vitamin B12 supplementation on DNA methylation https://www.wcrf.org/int/research-we-fund/what-we-re-funding/effect-folic-acid-and-vitamin-b12-supplementation-dna

11. DNA Methylation Modifications Associated with Chronic Fatigue Syndrome: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0104757

12. Mitochondrial dysfunction and molecular pathways of disease. https://www.ncbi.nlm.nih.gov/pubmed/17239370

13. TheBmj Mitochondrial research: https://www.bmj.com/content/335/7623/747

14. Association of mitochondrial dysfunction and fatigue: A review of the literature. https://www.sciencedirect.com/science/article/pii/S221464741400004X